Quercetin-modulated erythrocyte membrane sodium-hydrogen exchanger during human aging: correlation with atpase's

Quercetin-modulated erythrocyte membrane sodium-hydrogen exchanger during human aging: correlation with atpase's

Author Kumar, Prabhanshu Google Scholar
Chand, Subhash Google Scholar
Maurya, Pawan Kumar Autor UNIFESP Google Scholar
Abstract Content: Quercetin uptake by erythrocytes is rapid. The sodium-hydrogen exchanger (NHE) is a secondary active transporter, regulating intracellular pH, Na+ concentration and cell volume. Objective: The aim of present study was to investigate NHE as a function of human age and effect of quercetin on its activity. The NHE activity was correlated with erythrocytes ATPases. Materials and methods: We analyzed normal, healthy subjects of both sexes (20-82 years). NHE activity was estimated in terms of amiloride-sensitive H+-efflux from acid-loaded cells. Results: A significant age-dependent increase in NHE activity was observed during aging in humans. Concentration (10(-3) M to 10(-8) M)-dependent in vitro treatment with quercetin causes inhibition of NHE activity. The Na+/K+ -ATPase (r = 0.8882) and Ca2+-ATPase (r = 0.9540) activities positively correlated with it. Discussion and conclusion: The present data show an additional mechanism where dietary flavonoids may exerts beneficial effect during aging.
Keywords Aging
Ca2+-Atpase
Na+/H+ Exchanger
Na+/K+-Atpase
QuercetinNa+/H+ Exchanger
Enzyme-Activities
Acidic Ph
Human Age
Cells
Transport
Cancer
Glutathione
Homeostasis
Inhibition
Language English
Sponsor coordination of Improvement of Higher Education Personnel (CAPES), National Counsel of Technological and Scientific Development (CNPq), Brazil
Date 2016
Published in Archives Of Physiology And Biochemistry. Abingdon, v. 122, n. 3, p. 141-147, 2016.
ISSN 1381-3455 (Sherpa/Romeo, impact factor)
Publisher Hindawi Ltd
Extent 141-147
Origin https://doi.org/10.3109/13813455.2016.1150299
Access rights Closed access
Type Article
Web of Science ID WOS:000386832300005
URI http://repositorio.unifesp.br/handle/11600/49357

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