The emerging role of mirnas and their clinical implication in biliary tract cancer

The emerging role of mirnas and their clinical implication in biliary tract cancer

Author Ferreira Martins, Nina Nayara Google Scholar
da Silva Oliveira, Kelly Cristina Google Scholar
Bona, Amanda Braga Google Scholar
Cardoso Smith, Marilia de Arruda Autor UNIFESP Google Scholar
Ishak, Geraldo Google Scholar
Assumpcao, Paulo Pimentel Google Scholar
Burbano, Rommel Rodriguez Google Scholar
Calcagno, Danielle Queiroz Google Scholar
Abstract Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra-and extrahepatic ducts and have a poor prognosis. Surgical resection remains themain curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several singlenucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.
Keywords Intrahepatic Cholangiocarcinoma Cells
North Indian Population
Gallbladder Cancer
Tumor-Suppressor
Gastric-Cancer
Genetic-Variants
Mesenchymal Transition
Epigenetic Regulation
Down-Regulation
C-Myc
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Date 2016
Published in Gastroenterology Research And Practice. New york, 2016.
ISSN 1687-6121 (Sherpa/Romeo, impact factor)
Publisher Editora Unilasalle
Origin http://dx.doi.org/10.1155/2016/9797410
Access rights Open access Open Access
Type Revisão
Web of Science ID WOS:000392001900001
URI http://repositorio.unifesp.br/handle/11600/49276

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