Advances and challenges on cancer cells reprogramming using induced pluripotent stem cells technologies

Advances and challenges on cancer cells reprogramming using induced pluripotent stem cells technologies

Author Dias Camara, Diana Aparecida Autor UNIFESP Google Scholar
Mambelli, Lisley Inata Google Scholar
Porcacchia, Allan Saj Google Scholar
Kerkis, Irina Google Scholar
Abstract Cancer cells transformation into a normal state or into a cancer cell population which is less tumorigenic than the initial one is a challenge that has been discussed during last decades and it is still far to be solved. Due to the highly heterogeneous nature of cancer cells, such transformation involves many genetic and epigenetic factors which are specific for each type of tumor. Different methods of cancer cells reprogramming have been established and can represent a possibility to obtain less tumorigenic or even normal cells. These methods are quite complex, thus a simple and efficient method of reprogramming is still required. As soon as induced pluripotent stem cells (iPSC) technology, which allowed to reprogram terminally differentiated cells into embryonic stem cells (ESC)-like, was developed, the method strongly attracted the attention of researches, opening new perspectives for stem cell (SC) personalized therapies and offering a powerful in vitro model for drug screening. This technology is also used to reprogram cancer cells, thus providing a modern platform to study cancer-related genes and the interaction between these genes and the cell environment before and after reprogramming, in order to elucidate the mechanisms of cancer initiation and progression. The present review summarizes recent advances on cancer cells reprogramming using iPSC technology and shows the progress achieved in such field.
Keywords Gastrointestinal Cancer
Ips Cells
Human Fibroblasts
Defined Factors
Somatic-Cells
Generation
Induction
Efficient
Hypoxia
Genome
Language English
Sponsor FAPESP (Sao Paulo Research Foundation) [2010/51051-6]
Grant number FAPESP: 2010/51051-6
Date 2016
Published in Journal Of Cancer. Lake haven, v. 7, n. 15, p. 2296-2303, 2016.
ISSN 1837-9664 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 2296-2303
Origin http://dx.doi.org/10.7150/jca.16629
Access rights Open access Open Access
Type Revisão
Web of Science ID WOS:000393093300017
URI http://repositorio.unifesp.br/handle/11600/49268

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