Cryopreserved adipose tissue-derived stromal/stem cells: potential for applications in clinic and therapy

Cryopreserved adipose tissue-derived stromal/stem cells: potential for applications in clinic and therapy

Author Zanata, Fabiana Autor UNIFESP Google Scholar
Shaik, Shahensha Google Scholar
Devireddy, Ram V. Google Scholar
Wu, Xiying Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Gimble, Jeffrey M. Google Scholar
Abstract Adipose-Derived Stromal/Stem Cells (ASC) have considerable potential for regenerative medicine due to their abilities to proliferate, differentiate into multiple cell lineages, high cell yield, relative ease of acquisition, and almost no ethical concerns since they are derived from adult tissue. Storage of ASC by cryopreservation has been well described that maintains high cell yield and viability, stable immunophenotype, and robust differentiation potential post-thaw. This ability is crucial for banking research and for clinical therapeutic purposes that avoid the morbidity related to repetitive liposuction tissue harvests. ASC secrete various biomolecules such as cytokines which are reported to have immunomodulatory properties and therapeutic potential to reverse symptoms of multiple degenerative diseases/disorders. Nevertheless, safety regarding the use of these cells clinically is still under investigation. This chapter focuses on the different aspects of cryopreserved ASC and the methods to evaluate their functionality for future clinical use.
Keywords Adipose-Derived Stromal/Stem Cells
Regenerative Medicine
Adipose Tissue
Human Cells
Cell Differentiation
Immunophenotype
Cryopreservation
Clinical TrialsAdult Stem-Cells
Experimental Autoimmune Encephalomyelitis
International-Society
Crohns Fistula
Autologous Transplantation
Assisted Lipotransfer
Stem/Stromal Cells
Position Statement
Calvarial Defects
Vascular Fraction
Language English
Date 2016
Published in Biobanking And Cryopreservation Of Stem Cells. Cham, v. 951, p. 137-146, 2016.
ISSN 0065-2598 (Sherpa/Romeo, impact factor)
Publisher Fac Latinoamericana Ciencias Sociales-Flacso, Ecuador
Extent 137-146
Origin https://doi.org/10.1007/978-3-319-45457-3_11
Access rights Closed access
Type Article
Book chapter
Web of Science ID WOS:000400699700012
URI http://repositorio.unifesp.br/handle/11600/49247

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