The imbalance of sex-hormones related to depressive symptoms in obese men

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dc.contributor.author Monteagudo, Patrícia Teófilo [UNIFESP]
dc.contributor.author Falcão, Adriana Andrade [UNIFESP]
dc.contributor.author Verreschi, Ieda Therezinha do Nascimento [UNIFESP]
dc.contributor.author Zanella, Maria-Teresa [UNIFESP]
dc.date.accessioned 2019-01-21T10:29:23Z
dc.date.available 2019-01-21T10:29:23Z
dc.date.issued 2016
dc.identifier https://doi.org/10.3109/13685538.2015.1084500
dc.identifier.citation Aging Male. Abingdon, v. 19, n. 1, p. 20-26, 2016.
dc.identifier.issn 1368-5538
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49199
dc.description.abstract Obese men may present hypogonadothrofic hypogonadism, mainly related to higher insulinemia and aromatase activity. Our objectives were to evaluate the relationship of sex-hormones profiles and frequency of depressive symptoms in 43 obese men, in a cross-sectional study. They had 19-60 years, and body mass index 30-50kg/m(2). LH, total and free testosterone (TT and FT), estradiol (E-2), sex hormone binding globulin, estradiol/total testosterone ratio (E-2/T) were analyzed. Depressive symptoms were evaluated by beck depression inventory (BDI), and significant depression was considered if BDI16.Thirty-four (80%) presented low TT levels, but only 4 (14%) had low free testosterone and hypogonadism symptoms en
dc.description.abstract 12 of 43 (28%) presented increased E-2. Forty five (56%) presented depressive symptoms, but 16 (28% of the 45) had significant depression. BDI correlated positively with E-2 (r=0.407 en
dc.description.abstract p=0.001) and E-2/T (r=0.473 en
dc.description.abstract p=0.001), but not TT or FT. Patients with significant depressive showed higher levels of estradiol (136 +/- 48 versus 103 +/- 48pg/ml, p=0.02) and E-2/T (16.0 +/- 9.9 versus 9.8 +/- 4.6 en
dc.description.abstract p=0.002) (mean +/- SD).In conclusion, obese men may present relatively excess of estradiol and deficiency in testosterone, leading to an imbalance between these two hormones. The greater this imbalance, the more depressive symptoms had our patients. en
dc.description.sponsorship Brazilian "National Council for ScientificResearch" (CNPq)
dc.format.extent 20-26
dc.language.iso eng
dc.publisher Univ Fed Rio De Janeiro, Fac Letras
dc.relation.ispartof Aging Male
dc.rights Acesso restrito
dc.subject Beck Inventory en
dc.subject Depressive Symptoms en
dc.subject Hypogonatropic Hypogonadism en
dc.subject Male ObesityTestosterone-Replacement Therapy en
dc.subject Androgen Receptor Polymorphism en
dc.subject Older Men en
dc.subject Hypogonadotropic Hypogonadism en
dc.subject Mood Disorders en
dc.subject Elderly-Men en
dc.subject Insulin en
dc.subject Anxiety en
dc.subject Serum en
dc.subject Association en
dc.title The imbalance of sex-hormones related to depressive symptoms in obese men en
dc.type Artigo
dc.description.affiliation Endocrinology Outpatient Clinic of Kidney and Hypertension Hospital and Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, Rua Leandro Dupret 365, BR-04025011, São Paulo, Brazil
dc.description.affiliationUnifesp Endocrinology Outpatient Clinic of Kidney and Hypertension Hospital and Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, Rua Leandro Dupret 365, BR-04025011, São Paulo, Brazil
dc.identifier.doi 10.3109/13685538.2015.1084500
dc.description.source Web of Science
dc.identifier.wos WOS:000372177200004



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