Effects of heart failure on cerebral blood flow in copd: rest and exercise

Effects of heart failure on cerebral blood flow in copd: rest and exercise

Author Oliveira, Mayron Faria Autor UNIFESP Google Scholar
Alencar, Maria Clara Autor UNIFESP Google Scholar
Arbex, Flavio Autor UNIFESP Google Scholar
Souza, Aline Autor UNIFESP Google Scholar
Sperandio, Priscila Autor UNIFESP Google Scholar
Medina, Luiz Autor UNIFESP Google Scholar
Medeiros, Wladimir Musetti Autor UNIFESP Google Scholar
Hirai, Daniel Müller Autor UNIFESP Google Scholar
O'Donnell, Denis E. Google Scholar
Neder, Jose Alberto Autor UNIFESP Google Scholar
Abstract Cerebral blood flow (CBF) and oxygenation (COx) are generally well-preserved in COPD. It is unknown whether prevalent cardiovascular co-morbidities, such as heart failure, may impair CBF and COx responses to exertion. Eighteen males with moderate-to-severe COPD (8 with and 10 without overlapping heart failure) underwent a progressive exercise test with pre-frontal CBF and COx measurements (indocyanine green and near-infrared spectroscopy). Mean arterial pressure and cardiac output were lower from rest to exercise in overlap. Only COPD patients demonstrated an increase in arterialized PCO2 towards the end of progressive exercise. CBF index was consistently higher and increased further by similar to 40% during exercise in COPD whereas a similar to 10% reduction was observed in overlap. COx was lower in overlap despite preserved arterial oxygenation. In conclusion, heart failure introduces pronounced negative effects on CBF and COx in COPD which may be associated with clinically relevant outcomes, including dyspnea, exercise intolerance, cerebrovascular disease and cognitive impairment. (C) 2015 Elsevier B.V. All rights reserved.
Keywords Cerebral Oxygenation
Chronic Obstructive Pulmonary Disease
Comorbidity
Near-Infrared SpectroscopyObstructive Pulmonary-Disease
Near-Infrared Spectroscopy
Cerebrovascular Responses
Noninvasive Measurement
Ejection Fraction
Indocyanine Green
Cardiac-Output
Oxygenation
Mechanisms
Cortex
Language English
Date 2016
Published in Respiratory Physiology & Neurobiology. Amsterdam, v. 221, p. 41-48, 2016.
ISSN 1569-9048 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 41-48
Origin https://doi.org/10.1016/j.resp.2015.10.005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000368208500006
URI http://repositorio.unifesp.br/handle/11600/49183

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