Proximal tubular dysfunction as an indicator of chronic graft dysfunction

Proximal tubular dysfunction as an indicator of chronic graft dysfunction

Autor Câmara, Niels Olsen Saraiva Autor UNIFESP Google Scholar
Williams Jr., W.w. Google Scholar
Pacheco-Silva, Alvaro Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Harvard University Massachusetts General Hospital
Instituto Israelita de Ensino e Pesquisa Hospital Albert Einstein Unidade de Transplante Renal
Resumo New strategies are being devised to limit the impact of renal sclerosis on graft function. Individualization of immunosuppression, specifically the interruption of calcineurin-inhibitors has been tried in order to promote better graft survival once chronic graft dysfunction has been established. However, the long-term impact of these approaches is still not totally clear. Nevertheless, patients at higher risk for tubular atrophy and interstitial fibrosis (TA/IF) development should be carefully monitored for tubular function as well as glomerular performance. Since tubular-interstitial impairment is an early event in TA/IF pathogenesis and associated with graft function, it seems reasonable that strategies directed at assessing tubular structural integrity and function would yield important functional and prognostic data. The measurement of small proteins in urine such as α-1-microglobulin, N-acetyl-beta-D-glucosaminidase, alpha/pi S-glutathione transferases, β-2 microglobulin, and retinol binding protein is associated with proximal tubular cell dysfunction. Therefore, its straightforward assessment could provide a powerful tool in patient monitoring and ongoing clinical assessment of graft function, ultimately helping to facilitate longer patient and graft survival associated with good graft function.
Palavra-chave Renal transplantation
Tubular proteins
Proximal tubular dysfunction
Chronic allograft nephropathy
Retinol binding protein
Idioma Inglês
Data de publicação 2009-03-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 3, p. 229-236, 2009.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 229-236
Fonte http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000264200100003
SciELO S0100-879X2009000300003 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4911

Exibir registro completo




Arquivo

Nome: S0100-879X2009000300003.pdf
Tamanho: 75.56KB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta