Sarcopenia, em pacientes com doença renal crônica: prevalência e associação com mortalidade

Sarcopenia, em pacientes com doença renal crônica: prevalência e associação com mortalidade

Autor Pereira, Raissa Antunes Autor UNIFESP Google Scholar
Orientador Kaneko, Maria Ayako Kamimura Kaneko Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Pós-graduação Nutrição
Resumo Background: In chronic kidney disease (CKD) multiple metabolic and nutritional abnormalities contribute to impairment of skeletal muscle mass and function thus predisposing patients to the condition of sarcopenia. Herein, we investigated the prevalence and mortality predictive power of sarcopenia, defined by three different methods, in non-dialysis-dependent (NDD) CKD patients. Methods: We evaluated 287 NDD-CKD patients stage 3-5 [59.9±10.5 years; 62% men; 49% diabetics; glomerular filtration rate (GFR) 25.0±15.8 ml/min/1.73m2]. Sarcopenia was defined as reduced muscle function assessed by handgrip strength (<30th percentile of a population-based reference adjusted for sex and age) plus diminished muscle mass assessed by three different methods: A) midarm muscle circumference <90% of reference value; B) muscle wasting by subjective global assessment; and C) reduced skeletal muscle mass index (<10.76kg/m² men; <6.76kg/m² women) estimated by bioelectrical impedance analysis (BIA). Patients were followed for up to 40 months for all-cause mortality and there was no loss of follow-up. Results: The prevalence of sarcopenia was 9.8% (A), 9.4% (B) and 5.9% (C). The kappa agreement between the methods were 0.69 (A vs B), 0.49 (A vs C) and 0.46 (B vs C). During follow-up, 51 patients (18%) died, and the frequency of sarcopenia was significantly higher among non-survivors.In crude Cox analysis, sarcopenia diagnosed by the three methods was associated with a higher hazard for mortality; however, only sarcopenia diagnosed by method C remained as a predictor of mortality after multivariate adjustment. Conclusions: The prevalence of sarcopenia in CKD patients on conservative therapy varies according to the method applied. Sarcopenia defined as reduced handgrip strength and low skeletal muscle mass index estimated by BIA was an independent predictor of mortality in these patients.
Assunto sarcopenia
massa muscular
força de preensão manual
doença renal crônica
mortalidade
Idioma Português
Data 2014-09-30
Publicado em PEREIRA, Raissa Antunes. Sarcopenia, em pacientes com doença renal crônica: prevalência e associação com mortalidade. 2014. Dissertação (Mestrado) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2014.
Linha de pesquisa Nutrição
Área de concentração Ciências da saúde
Editor Universidade Federal de São Paulo (UNIFESP)
Fonte https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=1596297
Direito de acesso Acesso restrito
Tipo Dissertação de mestrado
URI http://repositorio.unifesp.br/handle/11600/48896

Mostrar registro completo




Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)