Marcadores de angiogênese e dopplervelocimetria útero placentária em pacientes com restrição do crescimento fetal

Marcadores de angiogênese e dopplervelocimetria útero placentária em pacientes com restrição do crescimento fetal

Author Zamarian, Ana Cristina Perez Autor UNIFESP Google Scholar
Advisor Nardozza, Luciano Marcondes Machado Nardozza Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Graduate program Medicina (Obstetrícia)
Abstract Objective: Assessing the levels of sFlt-1, sEng, adiponectin, ADAM-12, PAPP-A, ANGI-2, VEGF, TGF-? and PP13 in pregnant women with fetal growth restriction (FGR) and controls. Methods: This case?control study included 66 patients with FGR and 64 healthy controls at 24-41 weeks´ gestation. Maternal serum levels of sFlt-1, sEng, adiponectin, ADAM-12, PAPP-A, ANGI-2, VEGF, PP13 and TGF-? were determined by ELISA method and uterine artery Doppler studies were performed. Results: Concentrations of sFlt-1, sEng, PAPP-A were significantly higher in FGR patients than controls (p<0.0001, p=0.02 and p=0.03, respectively). Concentration of ADAM-12, ANGI-2 (p=0.05 and p<0.0001) were significantly lower in FGR than controls. Increased sEng concentrations were correlated with abnormal uterine Doppler in FGR. Adiponectin and TGF-? were not associated with any analyzed parameters. Conclusion: Patients with FGR showed increased serum levels of sFlt-1, sEng and PAPP-A and decreased levels of ADAM-12 and ANGI-2. Moreover, we observed a positive association between elevated concentrations of sEng and changing impedance uterine artery Dopplervelocimetry.
Keywords angiogenic factors
fetal growth restriction
dopplervelocimetry
Language Portuguese
Date 2014-07-30
Published in ZAMARIAN, Ana Cristina Perez. Marcadores de angiogênese e dopplervelocimetria útero placentária em pacientes com restrição do crescimento fetal. 2014. 81 f. Dissertação (Mestrado) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2014.
Research area Medicina
Knowledge area Ciências da saúde
Publisher Universidade Federal de São Paulo (UNIFESP)
Extent 81 p.
Origin https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=1759104
Access rights Closed access
Type Dissertation
URI http://repositorio.unifesp.br/handle/11600/48640

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