Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in leprosy patients with articular involvement

Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in leprosy patients with articular involvement

Autor Ribeiro, Sandra Lúcia Euzébio Autor UNIFESP Google Scholar
Pereira, H.l.a. Autor UNIFESP Google Scholar
Silva, Neusa Pereira da Autor UNIFESP Google Scholar
Neves, R.m.s. Autor UNIFESP Google Scholar
Sato, Emilia Inoue Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Amazonas Disciplina de Reumatologia
Resumo The objective of the present research was to evaluate the usefulness of anti-cyclic citrullinated peptide (anti-CCP) antibodies and the IgM rheumatoid factor (IgM RF) test for the differential diagnosis of leprosy with articular involvement and rheumatoid arthritis (RA). Anti-CCP antibodies and IgM RF were measured in the sera of 158 leprosy patients (76 with and 82 without articular involvement), 69 RA patients and 89 healthy controls. Leprosy diagnosis was performed according to Ridley and Jopling classification criteria and clinical and demographic characteristics of leprosy patients were collected by a standard questionnaire. Leprosy patients with any concomitant rheumatic disease were excluded. Serum samples were obtained from all participants and frozen at _20°C. Measurement of anti-CCP antibodies and IgM RF were performed by ELISA, using a commercial second-generation kit, and the latex agglutination test, respectively. Anti-CCP antibodies and IgM RF were detected in low frequencies (2.6 and 1.3%, respectively) in leprosy patients and were not associated with articular involvement. Among healthy individuals both anti-CCP antibodies and IgM RF were each detected in 3.4% of the subjects. In contrast, in the RA group, anti-CCP antibodies were present in 81.2% and IgM RF in 62.3%. In the present study, both anti-CCP antibodies and IgM RF showed good positive predictive value for RA, helping to discriminate between RA and leprosy patients with articular involvement. However, anti-CCP antibodies were more specific for RA diagnosis in the population under study.
Palavra-chave Leprosy
Rheumatoid arthritis
Anti-cyclic citrullinated peptide antibodies
Rheumatoid factor
Idioma Inglês
Data de publicação 2008-11-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 11, p. 1005-1010, 2008.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1005-1010
Fonte http://dx.doi.org/10.1590/S0100-879X2008001100010
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000261960500010
SciELO S0100-879X2008001100010 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4623

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