Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats

Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats

Autor Assis, L. Autor UNIFESP Google Scholar
Milares, L. P. Autor UNIFESP Google Scholar
Almeida, T. Google Scholar
Tim, C. Google Scholar
Magri, A. Autor UNIFESP Google Scholar
Fernandes, K. R. Autor UNIFESP Google Scholar
Medalha, C Autor UNIFESP Google Scholar
Renno, A. C. Muniz Autor UNIFESP Google Scholar
Resumo Objective: The aim of this study was to evaluate the effects of an aerobic exercise training and low-level laser therapy (LLLT) (associated or not) on degenerative modifications and inflammatory mediators on the articular cartilage using an experimental model of knee OA. Material and methods: Fifty male Wistar rats were randomly divided into five groups: control group (CG) knee OA control group (OAC) OA plus exercise training group (OAT) OA plus LLLT group (OAL) OA plus exercise training associated with LLLT group (OATL). The exercise training (treadmill 16 m/min 50 min/day) and the laser irradiation (two points-medial and lateral side of the left joint 24 sessions) started 4 weeks after the surgery, 3 days/week for 8 weeks. Results: The results showed that all treated groups showed (irradiated or not) a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and chondrocytes organization, a lower degenerative process measured by OARSI score and higher thickness values. Additionally, all treated group showed a reduced expression in IL-1 beta, caspase-3 and MMP-13 compared to OAC. Moreover, a lower caspase-3 expression was observed in OATL compared to OAL and OAT. Conclusion: These results suggest that exercise training and LLLT were effective in preventing cartilage degeneration and modulating inflammatory process induced by knee OA.
Assunto Low-level laser therapy
Articular cartilage
Knee osteoarthritis
RehabilitationCartilage Matrix Degradation
Biomechanical Signals
Oxidative Stress
Controlled-Trial
Joint
Expression
Protocol
Pain
Apoptosis
Rabbit
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 2012-20145-0
Data 2016
Publicado em Osteoarthritis And Cartilage. Oxford, v. 24, n. 1, p. 169-177, 2016.
ISSN 1063-4584 (Sherpa/Romeo, fator de impacto)
Editor Elsevier Sci Ltd
Extensão 169-177
Fonte http://dx.doi.org/10.1016/j.joca.2015.07.020
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000366839100020
URI http://repositorio.unifesp.br/handle/11600/46087

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