Update on Thin Melanoma: Outcome of an International Workshop

Update on Thin Melanoma: Outcome of an International Workshop

Author Mihic-Probst, Daniela Google Scholar
Shea, Chris Google Scholar
Duncan, Lyn Google Scholar
de la Fouchardiere, Arnaud Google Scholar
Landman, Gilles Autor UNIFESP Google Scholar
Landsberg, Jennifer Google Scholar
ven den Oord, Joost Google Scholar
Lowe, Lori Google Scholar
Cook, Martin G. Google Scholar
Yun, Sook Jung Google Scholar
Clarke, Loren Google Scholar
Messina, Jane Google Scholar
Elder, David E. Google Scholar
Barnhill, Raymond L. Google Scholar
Abstract The following communication summarizes the proceedings of a 1-day Workshop of the International Melanoma Pathology Study Group, which was devoted to thin melanoma. The definitions and histologic criteria for thin melanoma were reviewed. The principal differential diagnostic problems mentioned included the distinction of thin melanoma from nevi, especially from nevi of special site, irritated nevi, inflamed and regressing nevi, and dysplastic nevi. Histologic criteria for this analysis were discussed and the importance of clinico-pathologic correlation, especially in acral sites, was emphasized. Criteria for the minimal definition of invasion were also discussed. In addition, a new technique of m-RNA expression profiling with 14 genes was presented and facilitated the distinction of thin melanomas from nevus in histologically obvious cases. However, for particular nevi, it was not obvious why the results indicated a malignant lesion. Despite many molecular and other ancillary investigations, Breslow thickness remains the most important prognostic factor in thin melanoma. The prognostic significance of radial (horizontal) and vertical growth phases, Clark level, regression, and mitotic rate were also discussed. Because of the increasing frequency of thin melanomas, there is a great need to develop more refined predictors of thin melanomas with worse clinical outcome.
Keywords thin melanoma
Breslow thickness
mitotic rate
growth phase
regression
angiotropismCutaneous Malignant-Melanoma
Tumor Progression
Metastasis
Predictors
Regression
Thickness
Diagnosis
Survival
Invasion
Trends
Language English
Sponsor Cancer Research UK [22308]
Date 2016
Published in Advances In Anatomic Pathology. Philadelphia, v. 23, n. 1, p. 24-29, 2016.
ISSN 1072-4109 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 24-29
Origin http://dx.doi.org/10.1097/PAP.0000000000000100
Access rights Closed access
Type Review
Web of Science ID WOS:000366939500003
URI http://repositorio.unifesp.br/handle/11600/46073

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