Methyl-CpG-Binding Protein (MBD) Family: Epigenomic Read-Outs Functions and Roles in Tumorigenesis and Psychiatric Diseases

Methyl-CpG-Binding Protein (MBD) Family: Epigenomic Read-Outs Functions and Roles in Tumorigenesis and Psychiatric Diseases

Author Gigek, Carolina Oliveira Autor UNIFESP Google Scholar
Chen, Elizabeth Suchi Autor UNIFESP Google Scholar
Smith, Marilia Arruda Cardoso Autor UNIFESP Google Scholar
Abstract Epigenetics is the study of the heritable changes on gene expression that are responsible for the regulation of development and that have an impact on several diseases. However, it is of equal importance to understand how epigenetic machinery works. DNA methylation is the most studied epigenetic mark and is generally associated with the regulation of gene expression through the repression of promoter activity and by affecting genome stability. Therefore, the ability of the cell to interpret correct methylation marks and/or the correct interpretation of methylation plays a role in many diseases. The major family of proteins that bind methylated DNA is the methyl-CpG binding domain proteins, or the MBDs. Here, we discuss the structure that makes these proteins a family, the main functions and interactions of all protein family members and their role in human disease such as psychiatric disorders and cancer. (C) 2015 Wiley Periodicals, Inc.
Keywords Methyl-Cpg Binding Protein
Epigenetics
Dna Methylation
Cancer
Autism
Schizophrenia2q23.1 Microdeletion Syndrome
Histone Deacetylase Complex
Epigenetic Down-Regulation
Colon-Cancer Cells
Stem-Cells
Dna Methylation
Neurodevelopmental Disorders
Glu346lys Polymorphism
Chinese Population
Autistic Patients
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2016
Published in Journal Of Cellular Biochemistry. Hoboken, v. 117, n. 1, p. 29-38, 2016.
ISSN 0730-2312 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 29-38
Origin http://dx.doi.org/10.1002/jcb.25281
Access rights Closed access
Type Article
Web of Science ID WOS:000368229800003
URI http://repositorio.unifesp.br/handle/11600/46051

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