Dopamine D2 receptor gene polymorphisms and externalizing behaviors in children and adolescents

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dc.contributor.author Della Torre, Osmar Henrique
dc.contributor.author Paes, Lucia Arisaka
dc.contributor.author Henriques, Taciane Barbosa
dc.contributor.author Mello, Maricilda Palandi de [UNIFESP]
dc.contributor.author Celeri, Eloisa Helena Rubello Valler
dc.contributor.author Dalgalarrondo, Paulo
dc.contributor.author Guerra-Junior, Gil
dc.contributor.author Santos-Junior, Amilton dos
dc.date.accessioned 2018-07-26T12:18:49Z
dc.date.available 2018-07-26T12:18:49Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1186/s12881-018-0586-9
dc.identifier.citation Bmc Medical Genetics. London, v. 19, p. -, 2018.
dc.identifier.issn 1471-2350
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/46046
dc.description.abstract Background: Dopamine is involved in several cerebral physiological processes, and single nucleotide polymorphisms (SNP) in the dopamine D2 receptor gene (DRD2) have been associated with numerous neurological and mental disorders, including those involving alterations in cognitive and emotional processes. Methods: The aim of this study was to evaluate the association between the SNPs c.957C > T (rs6277) and c.-585A > G (rs1799978) in the DRD2 gene and behavioral characteristics of children and adolescents based on an inventory of the Child Behavior Checklist (CBCL). Children and adolescents between 8 and 20 years old who were clinically followed-up were genotyped for the SNPs c.957C > T and c.-585A > G, and related to data of the CBCL/6-18 scale assessment performed with the help of caregivers. The chi-squared test was used to assess the differences in the frequencies of the C and T alleles in the polymorphism c.957C >T and of the A and G alleles in the polymorphism c.-585A > G with respect to the grouped CBCL scores at a significance level of 5%. Multiple logistic regression models were performed, to control whether sex and/or ethnicity could influence the results. Results: Eighty-five patients were assessed overall, and the presence of the T allele (C/T and T/T) of DRD2 c.957C > T polymorphism was found to be significantly associated with the occurrence of defiant and oppositional problems and with attention and hyperactivity problems. There were no associations detected with polymorphism DRD2 c.-585A > G polymorphism. Both SNPs were in Hardy-Weinberg-equilibrium. Conclusions: Although the findings of this study are preliminary, due to its small number of participants, the presence of T allele (C/T, T/T) in c.957C > T SNP was associated with difficulty in impulse control, self-control of emotions, and conduct adjustment, which can contribute to improving the identification of mental and behavioral phenotypes associated with gene expression. en
dc.description.sponsorship Sao Paulo Research Foundation (FAPESP)
dc.format.extent -
dc.language.iso eng
dc.publisher Biomed Central Ltd
dc.rights Acesso aberto
dc.subject Genetic polymorphism en
dc.subject Dopamine en
dc.subject Behavior en
dc.subject c.957C > T polymorphism en
dc.subject c.-585A > G polymorphism en
dc.title Dopamine D2 receptor gene polymorphisms and externalizing behaviors in children and adolescents en
dc.type Artigo
dc.description.affiliation [Della Torre, Osmar Henrique
dc.description.affiliation Paes, Lucia Arisaka
dc.description.affiliation Rubello Valler Celeri, Eloisa Helena
dc.description.affiliation Dalgalarrondo, Paulo
dc.description.affiliation dos Santos-Junior, Amilton] State Univ Campinas Unicamp, FCM, Dept Psychiat, Campinas, SP, Brazil
dc.description.affiliation [Henriques, Taciane Barbosa
dc.description.affiliation de Mello, Maricilda Palandi] Univ Estadual Campinas, Ctr Mol Biol & Genet Engn CBMEG, Lab Human Genet, Campinas, SP, Brazil
dc.description.affiliation [Guerra-Junior, Gil] Univ Estadual Campinas, FCM, Ctr Invest Pediat CIPED, Growth & Dev Lab, Campinas, SP, Brazil
dc.description.affiliation [Guerra-Junior, Gil] Univ Estadual Campinas, FCM, Pediat Endocrinol Unit, Dept Pediat, Campinas, SP, Brazil
dc.description.affiliation [Della Torre, Osmar Henrique] Rua Tessalia Vieira Camargo 126, BR-13083887 Campinas, SP, Brazil
dc.description.affiliationUnifesp Univ Fed São Paulo
dc.description.sponsorshipID FAPESP: 2012/14005-1
dc.identifier.file WOS000431622900001.pdf
dc.identifier.doi 10.1186/s12881-018-0586-9
dc.description.source Web of Science
dc.identifier.wos WOS:000431622900001



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