Evidence for Mitochondrial Genome Methylation in the Yeast Candida albicans: A Potential Novel Epigenetic Mechanism Affecting Adaptation and Pathogenicity?

Evidence for Mitochondrial Genome Methylation in the Yeast Candida albicans: A Potential Novel Epigenetic Mechanism Affecting Adaptation and Pathogenicity?

Author Bartelli, Thais Fernanda Autor UNIFESP Google Scholar
Bruno, Danielle C. F. Google Scholar
Briones, Marcelo Ribeiro da Silva Autor UNIFESP Google Scholar
Abstract The commensal yeast Candida albicans is an opportunistic pathogen. In order to successfully colonize or infect the human body, the fungus must adapt to the host's environmental conditions, such as low oxygen tension (hypoxia), temperature (37 degrees C), and the different carbon sources available. Previous studies demonstrated the adaptive importance of C. albicans genetic variability for its pathogenicity, although the contributions of epigenetic and the influence of environmental factors are not fully understood. Mitochondria play important roles in fungal energetic metabolism, regulation of nuclear epigenetic mechanisms and pathogenicity. However, the specific impact of inter-strain mitochondrial genome variability and mitochondrial epigenetics in pathogenicity is unclear. Here, we draw attention to this relevant organelle and its potential role in C. albicans pathogenicity and provide preliminary evidence, for the first time, for methylation of the yeast mitochondrial genome. Our results indicate that environmental conditions, such as continuous exposure for 12 weeks to hypoxia and 37 degrees C, decrease the mitochondrial genome methylation in strains SC5314 and L757. However, the methylation decrease is quantitatively different in specific genome positions when strains SC5314 and L757 are compared. We hypothesize that this phenomenon can be promising for future research to understand how physical factors of the host affect the C. albicans mitochondrial genome and its possible impact on adaptation and pathogenicity.
Keywords Candida albicans
mitochondrial genome methylation
mtDNA
hypoxia
heat shock
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
Grant number FAPESP: 2013/08457-0
FAPESP: 2013/07838-0
CNPq: 303905/2013-1
Date 2018
Published in Frontiers In Genetics. Lausanne, v. 9, p. -, 2018. Article 166.
ISSN 1664-8021 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fgene.2018.00166
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000433385300001
URI http://repositorio.unifesp.br/handle/11600/46024

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