Reduced substantia innominata volume mediates contributions of microvascular and macrovascular disease to cognitive deficits in Alzheimer's disease

Reduced substantia innominata volume mediates contributions of microvascular and macrovascular disease to cognitive deficits in Alzheimer's disease

Author Jaswal, Gurpreet Google Scholar
Swardfager, Walter Google Scholar
Gao, Fu-qiang Google Scholar
Nestor, Sean M. Google Scholar
Ganda, Anoop Google Scholar
Cogo-Moreira, Hugo Autor UNIFESP Google Scholar
Sahlas, Demetrios J. Google Scholar
Stuss, Donald T. Google Scholar
Moody, Alan Google Scholar
Black, Sandra E. Google Scholar
Abstract The relationships between cholinergic system damage and cerebrovascular disease are not entirely understood. Here, we investigate associations between atrophy of the substantia innominata (SI

the origin of cortical cholinergic projections) and measures of large and small vessel disease

specifically, elongation of the juxtaposed internal carotid artery termination and Cholinergic Pathways Hyperintensity scores (CHIPS). The study (n = 105) consisted of patients with Alzheimer's disease (AD) and/or subcortical ischemic vasculopathy, and elderly controls. AD and subcortical ischemic vasculopathy groups showed greater impingement of the carotid termination on the SI and smaller SI volumes. Both carotid termination elongation and CHIPS were associated independently with smaller SI volumes in those with and without AD. Atrophy of the SI mediated effects of carotid termination elongation on language and memory functions and the effect of CHIPS on attention/working memory. In conclusion, SI atrophy was related to cerebrovascular disease of the large and small vessels and to cognitive deficits in people with and without AD. (C) 2018 Elsevier Inc. All rights reserved.
Keywords Alzheimer's disease
Substantia innominata
Cerebrovascular disorders
Vascular dementia
Internal carotid artery diseases
Language English
Sponsor Heart and Stroke Foundation of Canada
Canadian Institute for Health Research (CIHR)
Alzheimer Society of Canada
Alzheimer's Association US
LC Campbell Foundation
the Alzheimer's Association Research Grant Program Brain Canada
Grant number MOP: 13129
AARG: 501466
Date 2018
Published in Neurobiology Of Aging. New York, v. 66, p. 23-31, 2018.
ISSN 0197-4580 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 23-31
Origin http://dx.doi.org/10.1016/j.neurobiolaging.2018.01.025
Access rights Closed access
Type Article
Web of Science ID WOS:000431006300003
URI http://repositorio.unifesp.br/handle/11600/46017

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