Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia

Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia

Author Veloso, Aparecida Gabriela Bexiga Google Scholar
Lima, Nathalia Edviges Alves Google Scholar
Ornelas, Elisabete de Marco Google Scholar
Cardoso, Clever Gomes Google Scholar
Marques, Mara Rubia Google Scholar
Reis, Beatriz da Costa Aguiar Alves Google Scholar
Fonseca, Fernando Luiz Affonso Autor UNIFESP Google Scholar
Maifrino, Laura Beatriz Mesiano Google Scholar
Abstract Menopausal women are at high risk of developing heart disease. However, physical exercise practice can reverse this scenario. We evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for LDL receptor with estrogen deprivation by ovariectomy. Animals were divided into six groups (n = 5): sedentary non-ovariectomized control

sedentary ovariectomized control

trained ovariectomized control

sedentary non-ovariectomized LDL-R knockout

sedentary ovariectomized LDL-R knockout

and trained ovariectomized LDL-R knockout. Physical exercise practice promoted improvement in biometric and biochemical parameters analyzed, with reduction of visceral adipose tissue and VLDL, triglycerides, total cholesterol, and blood glucose levels. In addition, physical exercise practice altered the morphology of pancreatic islets and improved their response to the effects of menopause. Thus, physical exercise practice was fundamental to minimize the effects of dyslipidemia associated with ovariectomy in the pancreatic tissue of LDL-R knockout animals, contributing to reduce the risk of developing cardiac diseases in the menopause period.
Keywords Dyslipidemia
Pancreas
Physical exercise
Menopause
Estrogen deprivation
Language English
Date 2018
Published in Medical Molecular Morphology. Tokyo, v. 51, n. 2, p. 118-127, 2018.
ISSN 1860-1480 (Sherpa/Romeo, impact factor)
Publisher Springer Japan Kk
Extent 118-127
Origin http://dx.doi.org/10.1007/s00795-018-0179-x
Access rights Closed access
Type Article
Web of Science ID WOS:000432714400007
URI http://repositorio.unifesp.br/handle/11600/46002

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