Delta sleep instability in children with chronic arthritis

Delta sleep instability in children with chronic arthritis

Author Lopes, Maria Cecília Autor UNIFESP Google Scholar
Guilleminault, Christian Google Scholar
Rosa, Agostinho da Google Scholar
Passarelli, Cassia Autor UNIFESP Google Scholar
Roizenblatt, Suely Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Stanford University Sleep Disorders Clinic
Evolutionary Systems and Biomedical Engineering Laboratory
Abstract The objective of the present study was to evaluate the expression of a cyclic alternating pattern (CAP) in slow wave sleep (SWS) in children with the well-defined chronic syndrome juvenile idiopathic arthritis (JIA). Twelve patients (9-17 years of age), 7 girls, with JIA were compared to matched controls by age, pubertal stage and gender. After one night of habituation in the sleep laboratory, sleep measurements were obtained by standard polysomnography with conventional sleep scoring and additional CAP analyses. The sleep parameters of the JIA and control groups were similar for sleep efficiency (91.1 ± 6.7 vs 95.8 ± 4.0), sleep stage in minutes: stage 1 (16.8 ± 8.5 vs 17.8 ± 4.0), stage 2 (251.9 ± 41 vs 262.8 ± 38.1), stage 3 (17.0 ± 6.0 vs 15.1 ± 5.7), stage 4 (61.0 ± 21.7 vs 77.1 ± 20.4), and rapid eye movement sleep (82.0 ± 27.6 vs 99.0 ± 23.9), respectively. JIA patients presented nocturnal disrupted sleep, with an increase in short awakenings, but CAP analyses showed that sleep disruption was present even during SWS, showing an increase in the overall CAP rate (P < 0.01). Overall CAP rate during non-rapid eye movement sleep was significantly higher in pediatric patients who were in chronic pain. This is the first study of CAP in pediatric patients with chronic arthritis showing that CAP analyses can be a powerful tool for the investigation of disturbance of SWS in children, based on sleep EEG visual analysis.
Keywords Children
Chronic-arthritis
Cyclic alternating pattern
Sleep fragmentation
Language English
Date 2008-10-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 10, p. 938-943, 2008.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 938-943
Origin http://dx.doi.org/10.1590/S0100-879X2008001000018
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000261171400018
SciELO ID S0100-879X2008001000018 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/4582

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