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Title: Structural characterization of multilamellar liposomes coencapsulating curcumin and vitamin D-3
Authors: Chaves, Matheus Andrade
Oseliero Filho, Pedro Leonidas
Jange, Camila Garcia
Sinigaglia-Coimbra, Rita [UNIFESP]
Oliveira, Cristiano Luis Pinto
Pinho, Samantha Cristina
Keywords: Microencapsulation
Phospholipid vesicles
Small-angle X-ray scattering
Issue Date: 2018
Publisher: Elsevier Science Bv
Citation: Colloids And Surfaces A-Physicochemical And Engineering Aspects. Amsterdam, v. 549, p. 112-121, 2018.
Abstract: This study aimed the production of multilamellar liposomes coencapsulating two hydrophobic bioactives, curcumin and vitamin D-3, which present antioxidant and nutraceutical properties. Liposomes were produced by proliposomes hydration and stabilized with a mixture of xanthan and guar gums. Proliposomes were produced by coating of micronized sucrose method. Physicochemical properties of the dispersions were evaluated over 42 days of refrigerated storage. Microstructural characterization were performed by differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS) and small deformation rheological analyses. Liposomes showed spherical and near-spherical shapes and presented hydrodynamic diameters in the 680-1580 nm range. Curcumin and cholecalciferol were loaded into the same vesicles, with preservation efficiencies ranging from 89.6 to 93.3% and from 88.3 to 91.3%, respectively, after 42 days of storage. SAXS data showed that the lipid bilayer of liposomes produced in the presence of curcumin, vitamin D-3, or a mixture of both, are very similar. Also, higher amounts of vitamin D-3 did not affect negatively the stability of phospholipid vesicles. Overall, it was demonstrated that the coencapsulation of curcumin and vitamin D-3 by liposomes is feasible and high contents of bioactives were retained throughout the storage time.
ISSN: 0927-7757
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