Structural characterization of multilamellar liposomes coencapsulating curcumin and vitamin D-3

Structural characterization of multilamellar liposomes coencapsulating curcumin and vitamin D-3

Autor Chaves, Matheus Andrade Google Scholar
Oseliero Filho, Pedro Leonidas Google Scholar
Jange, Camila Garcia Google Scholar
Sinigaglia-Coimbra, Rita Autor UNIFESP Google Scholar
Oliveira, Cristiano Luis Pinto Google Scholar
Pinho, Samantha Cristina Google Scholar
Resumo This study aimed the production of multilamellar liposomes coencapsulating two hydrophobic bioactives, curcumin and vitamin D-3, which present antioxidant and nutraceutical properties. Liposomes were produced by proliposomes hydration and stabilized with a mixture of xanthan and guar gums. Proliposomes were produced by coating of micronized sucrose method. Physicochemical properties of the dispersions were evaluated over 42 days of refrigerated storage. Microstructural characterization were performed by differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS) and small deformation rheological analyses. Liposomes showed spherical and near-spherical shapes and presented hydrodynamic diameters in the 680-1580 nm range. Curcumin and cholecalciferol were loaded into the same vesicles, with preservation efficiencies ranging from 89.6 to 93.3% and from 88.3 to 91.3%, respectively, after 42 days of storage. SAXS data showed that the lipid bilayer of liposomes produced in the presence of curcumin, vitamin D-3, or a mixture of both, are very similar. Also, higher amounts of vitamin D-3 did not affect negatively the stability of phospholipid vesicles. Overall, it was demonstrated that the coencapsulation of curcumin and vitamin D-3 by liposomes is feasible and high contents of bioactives were retained throughout the storage time.
Assunto Microencapsulation
Phospholipid vesicles
Small-angle X-ray scattering
Cobertura Amsterdam
Idioma Inglês
Financiador FAPESP
CAPES (Coordination of Improvement of Staff Level Superior, BR)
CNPq (National Council for Scientific and Technological Development, BR)
Número do financiamento FAPESP: 2015/03362-6
FAPESP: 2014/23376-9
Data 2018
Publicado em Colloids And Surfaces A-Physicochemical And Engineering Aspects. Amsterdam, v. 549, p. 112-121, 2018.
ISSN 0927-7757 (Sherpa/Romeo, fator de impacto)
Editor Elsevier Science Bv
Extensão 112-121
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000432551500013

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