Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats

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dc.contributor.author Campos, Viviane Ferreira [UNIFESP]
dc.contributor.author Miranda-Ferreira, Regiane [UNIFESP]
dc.contributor.author Taha, Nabiha Saadi Abrahão [UNIFESP]
dc.contributor.author Teixeira, G. D.
dc.contributor.author Souza, W. T. I.
dc.contributor.author Carmo, C. E. F.
dc.contributor.author Silva-Neto, L. A.
dc.contributor.author Gomes, I. T.
dc.contributor.author Monteiro, Hugo Pequeno
dc.contributor.author Montero, Edna Frasson de Souza
dc.contributor.author Fagundes, Djalma Jose
dc.contributor.author Caricati-Neto, Afonso
dc.contributor.author Taha, Murched Omar [UNIFESP]
dc.date.accessioned 2018-06-18T12:15:09Z
dc.date.available 2018-06-18T12:15:09Z
dc.date.issued 2012-10-01
dc.identifier http://dx.doi.org/10.1016/j.transproceed.2012.07.058
dc.identifier.citation Transplantation Proceedings. New York: Elsevier Science Inc, v. 44, n. 8, p. 2313-2316, 2012.
dc.identifier.issn 0041-1345
dc.identifier.uri http://repositorio.unifesp.br/11600/45704
dc.description.abstract To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were treated with AT (1.5 mg . kg(-1), intravenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy analysis. Compared to the sham group, jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R. en
dc.format.extent 2313-2316
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Transplantation Proceedings
dc.rights Acesso aberto
dc.title Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Fed Univ Great Dourados
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Surg, BR-04023900 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Pharmacol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Biochem, BR-04023900 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Morphol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliation Fed Univ Great Dourados, Sch Med, Dourados, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Surg, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Pharmacol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Biochem, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Morphol, BR-04023900 Sao Paulo, Brazil
dc.identifier.file WOS000309736900015.pdf
dc.identifier.doi 10.1016/S0041-1345(98)01378-5
dc.description.source Web of Science
dc.identifier.wos WOS:000309736900015



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