Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats

Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats

Author Campos, Viviane Ferreira Autor UNIFESP Google Scholar
Miranda-Ferreira, Regiane Autor UNIFESP Google Scholar
Taha, Nabiha Saadi Abrahão Autor UNIFESP Google Scholar
Teixeira, G. D. Google Scholar
Souza, W. T. I. Google Scholar
Carmo, C. E. F. Google Scholar
Silva-Neto, L. A. Google Scholar
Gomes, I. T. Google Scholar
Monteiro, Hugo Pequeno Google Scholar
Montero, Edna Frasson de Souza Google Scholar
Fagundes, Djalma Jose Google Scholar
Caricati-Neto, Afonso Google Scholar
Taha, Murched Omar Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fed Univ Great Dourados
Abstract To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were treated with AT (1.5 mg . kg(-1), intravenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy analysis. Compared to the sham group, jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R.
Language English
Date 2012-10-01
Published in Transplantation Proceedings. New York: Elsevier Science Inc, v. 44, n. 8, p. 2313-2316, 2012.
ISSN 0041-1345 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2313-2316
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000309736900015

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