Endotoxins, asthma, and allergic immune responses

Endotoxins, asthma, and allergic immune responses

Author Silva, JR Lapa Google Scholar
Silva, MD Possebon da Autor UNIFESP Google Scholar
Lefort, J. Google Scholar
Vargaftig, B. B. Google Scholar
Institution Inst Pasteur
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract Asthma severity depends to a great extent on the levels of endotoxin present in the microenvironment. Although favouring a Th1 cytokine response that could be beneficial to the asthmatic, lipopolysaccharide (LPS) aggravates bronchopulmonary inflammation by several mechanisms. These include neutrophil and eosinophil recruitment, and release by activated macrophages of pro-inflammatory cytokines and nitric oxide. LPS exerts its biological actions through its interaction with CD14. The genetic locus of CD14 is close to the genomic region controlling levels of IgE. A polymorphism in the CD14 promoter region seems to favour high serum IgE levels. Genetic influences may thus control circulating levels of sCD14 and by this mechanism modulate Th1/Th2 balance and IgE synthesis. LPS exposure, although hazardous to the asthmatic, seems to exert a role in the maturation of the immune system in children towards a Th1-skewed pattern. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Keywords LPS
allergy
CD14
cytokines
Language English
Date 2000-11-02
Published in Toxicology. Clare: Elsevier Ireland Ltd, v. 152, n. 1-3, p. 31-35, 2000.
ISSN 0300-483X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 31-35
Origin http://dx.doi.org/10.1016/S0300-483X(00)00289-4
Access rights Closed access
Type Article
Web of Science ID WOS:000165627100005
URI http://repositorio.unifesp.br/11600/45666

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