Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil

Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil

Author Zannin, Marlene Google Scholar
Lourenco, Dayse Maria Autor UNIFESP Google Scholar
Motta, Guacyara Autor UNIFESP Google Scholar
Dalla Costa, Luís R. Google Scholar
Grando, Maargareth Google Scholar
Gamborgi, Geni P. Google Scholar
Noguti, Maria A. Autor UNIFESP Google Scholar
Chudzinski-Tavassi, Ana M. Google Scholar
Institution Inst Butantan
Universidade Federal de Santa Catarina (UFSC)
Universidade Federal de São Paulo (UNIFESP)
Chapeco Blood Ctr Santa Catarina
CIT SC
Abstract Haemostatic disorders caused by Lonomia obliqua caterpillars has reached epidemic proportions in southern Brazil. Here we evaluated coagulation and fibrinolysis in 105 patients after accidental contact with Lonomia obliqua caterpillars. Global coagulation tests were prolonged in most cases and patients were divided into 3 groups according to fibrinogen (Fg) level: less than or equal to0.5 g/l (group A); 0.51-1.5 g/l (group B), >1.5 g/l (group C). There was a significant reduction of factors V, XIII, VIII and prekallikrein in group A, with no change in factors X, II and von Willebrand factor. Thrombin-antithrombin and prothrombin F1+2 were elevated in most patients. Antithrombin and protein S were not changed whereas protein C levels were reduced in group A. Plasminogen and alfa2-antiplasmin levels were significantly reduced in group A and D-Dimer levels were extremely high in all groups, showing that fibrinolysis had been activated, possibly secondary to fibrin production. Levels of t-PA were normal and PAI-1 was mildly elevated in group A. The. platelet count remained above 150 X 10(9) platelets/ml in 97% of cases. In summary, our results suggest that Lonomia obliqua envenoming is characterized by a consumption coagulopathy and secondary fibrinolysis.
Keywords Lonomia obliqua
envenomation
fibrinolysis
coagulation
DIC
Language English
Date 2003-02-01
Published in Thrombosis And Haemostasis. Stuttgart: Schattauer Gmbh-verlag Medizin Naturwissenschaften, v. 89, n. 2, p. 355-364, 2003.
ISSN 0340-6245 (Sherpa/Romeo, impact factor)
Publisher Schattauer Gmbh-verlag Medizin Naturwissenschaften
Extent 355-364
Access rights Closed access
Type Article
Web of Science ID WOS:000181038200023
URI http://repositorio.unifesp.br/11600/45661

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