Combination Therapy with Methotrexate and Chloroquine in Rheumatoid Arthritis: A Multicenter Randomized Placebo-controlled Trial

Combination Therapy with Methotrexate and Chloroquine in Rheumatoid Arthritis: A Multicenter Randomized Placebo-controlled Trial

Author Ferraz, Marcos Bosi Autor UNIFESP Google Scholar
Pinheiro, Geraldo da Rocha Castelar Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Albuquerque, E. Google Scholar
Rezende, C. Google Scholar
Roimicher, Luis Google Scholar
Brandao, Leticia de Campos Autor UNIFESP Google Scholar
Silva, S. C. Google Scholar
Pinheiro, Geraldo da Rocha Castelar Google Scholar
Atra, Edgard Autor UNIFESP Google Scholar
Institution HOSP HELIOPOLIS
Universidade Federal do Rio de Janeiro (UFRJ)
INAMPS
HOSP BONSUCESSO
Universidade Federal de São Paulo (UNIFESP)
Abstract To compare the efficacy of the combination therapy Methotrexate (MTX) and Chloroquine (CHLO) with MTX and Placebo (PLA) in the treatment of Rheumatoid Arthritis.A total of 82 patients with Rheumatoid Arthritis (RA), diagnosed according to the American College of Rheumatology criteria, received orally either MTX 7.5 mg/week and CHLO 250 mg/day or MTX 7.5 mg/week and PLA 1 tablet/day. Adverse effects (AE) were monitored monthly and disease activity was assessed at 0, 2, 4 and 6 months.Sixty-eight patients completed the study. All outcome measures improved significantly in both treatment groups. Patients receiving MTX/CHLO ended the study with a significantly lower joint count, greater grip strength and better functional ability the patients in the MTX/PLA group, respectively; 4.5 vs 7.5 (P<0.05), 113.3 vs 89.1 (P<0.05) and 0.636 vs 0.811 (P<0.05). Mild AE were more frequently observed in the MTX/CHLO, 17 events in 15 patients, compared to 9 events in 8 patients in the MTX/PLA group (NS).These data indicate that MTX/CHLO is slightly more efficacious and toxic than is MTX/PLA in the treatment of RA.
Keywords METHOTREXATE
CHLOROQUINE
RHEUMATOID ARTHRITIS
CLINICAL TRIALS
COMBINATION THERAPY
OUTCOME MEASURES
FUNCTIONAL ABILITY
Language English
Date 1994-01-01
Published in Scandinavian Journal Of Rheumatology. Oslo: Scandinavian University Press, v. 23, n. 5, p. 231-236, 1994.
ISSN 0300-9742 (Sherpa/Romeo, impact factor)
Publisher Scandinavian University Press
Extent 231-236
Origin http://dx.doi.org/10.3109/03009749409103721
Access rights Closed access
Type Article
Web of Science ID WOS:A1994PQ59300002
URI http://repositorio.unifesp.br/11600/45574

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