Modulation of growth hormone secretion through the action of growth hormone secretagogues and ghrelin

Modulation of growth hormone secretion through the action of growth hormone secretagogues and ghrelin

Title: Modulation of growth hormone secretion through the action of growth hormone secretagogues and ghrelin;
Modulação da secreção do hormônio de crescimento pela (por la) ghrelina e secretagogos do hormônio de crescimento
Author Lengyel, Ana-Maria J. Autor UNIFESP Google Scholar
Paiva Cunha de Sa, Larissa Bianca Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Growth hormone-releasing hormone and somatostatin modulate growth hormone secretion. A third mechanism has been discovered in the last decade, involving the action of growth hormone secretagogues. Ghrelin is a new acylated peptide mainly produced by the stomach, but also synthesized in the hypothalamus. This compound increases both growth hormone release and food intake. The relative roles of hypothalamic and circulating ghrelin on growth hormone secretion are still unknown. Endogenous ghrelin might amplify the basic pattern of growth hormone secretion, optimizing somatotroph responsiveness to growth hormone-releasing hormone. This peptide activates multiple interdependent intracellular pathways at the somatotroph, involving protein kinase C, protein kinase A and extracellular calcium Systems. However, as ghrelin induces a greater release of growth hormone in vivo, its main site of action is the hypothalamus. In the current paper we review the available data on the discovery of this peptide, the mechanisms of action and possible physiological roles of growth hormone secretagogues and ghrelin on growth hormone secretion, and, finally, the regulation of growth hormone release in man after intravenous administration of these peptides.
Keywords ghrelin
growth hormone
secretagogues
Language Portuguese
Date 2008-11-01
Published in Salud I Ciencia. Buenos Aires: Soc Iberoamericana Informacion Cientifica-s I I C, v. 16, n. 5, p. 505-508, 2008.
ISSN 1667-8982 (Sherpa/Romeo, impact factor)
Publisher Soc Iberoamericana Informacion Cientifica-s I I C
Extent 505-508
Origin https://www.siicsalud.com/dato/sic/165/expertos165.pdf
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000263545500002
URI http://repositorio.unifesp.br/11600/45537

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account