Neurotoxicity and aggressiveness triggered by low-level lead in children: a review

Neurotoxicity and aggressiveness triggered by low-level lead in children: a review

Alternative title Neurotoxicidad y agresividad desencadenadas por bajos niveles de plomo en niños: una revisión
Author Olympio, Kelly Polido Kaneshiro Google Scholar
Gonçalves, Claudia Google Scholar
Güenther, Wanda Maria Risso Google Scholar
Bechara, Etelvino José Henriques Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Ctr Extensao Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract Lead-induced neurotoxicity acquired by low-level long-term exposure has special relevance for children. A plethora of recent reports has demonstrated a direct link between low-level lead exposure and deficits in the neurobehavioral-cognitive performance manifested from childhood through adolescence. In many studies, aggressiveness and delinquency have also been suggested as symptoms of lead poisoning. Several environmental, occupational and domestic sources of contaminant lead and consequent health risks are largely identified and understood, but the occurrences of lead poisoning remain numerous. There is an urgent need for public health policies to prevent lead poisoning so as to reduce individual and societal damages and losses. In this paper we describe unsuspected sources of contaminant lead, discuss the economic losses and urban violence possibly associated with lead contamination and review the molecular basis of lead-induced neurotoxicity, emphasizing its effects on the social behavior, delinquency and IQ of children and adolescents.
Keywords Lead poisoning
neurotoxicity syndromes
oxidative stress
juvenile delinquency
Language English
Date 2009-09-01
Published in Revista Panamericana De Salud Publica-pan American Journal Of Public Health. Washington: Pan Amer Health Organization, v. 26, n. 3, p. 266-275, 2009.
ISSN 1020-4989 (Sherpa/Romeo, impact factor)
Publisher Pan Amer Health Organization
Extent 266-275
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000270941500011
SciELO ID S1020-49892009000900011 (statistics in SciELO)

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