Statins and stroke: potential mechanisms for neurovascular protection

Show simple item record Fonseca, Francisco Antonio Helfenstein [UNIFESP] Franca, Carolina Nunes [UNIFESP] Póvoa, Rui Manuel dos Santos [UNIFESP] Izar, Maria Cristina de Oliveira [UNIFESP] 2018-06-18T11:54:25Z 2018-06-18T11:54:25Z 2010-11-01
dc.identifier.citation Revista De Neurologia. Barcelona: Revista De Neurologia, v. 51, n. 9, p. 551-560, 2010.
dc.identifier.issn 0210-0010
dc.description.abstract As the average human lifespan is increasing worldwide, ischemic stroke became one of the most important causes of mortality and morbidity, particularly in emerging countries. Significant decrease in the rates of first and recurrent stroke using statins has been established in large clinical trials and in systematic reviews and meta-analyses. Interestingly, observational studies reported that cholesterol levels were only weakly associated with ischemic stroke, suggesting that other potential mechanisms for vascular protection should be implicated. Indeed, beyond lipid changes, some properties of these drugs, related to inflammation, hemostasis, endothelial function, plague stabilization, and more recently, to the mobilization of endothelial cells, have been proposed. In addition, recent meta-analysis also revealed that statins decrease systolic and diastolic blood pressure. Taken together, all these benefits can contribute for stroke prevention by statins. en
dc.format.extent 551-560
dc.language.iso spa
dc.publisher Revista De Neurologia
dc.relation.ispartof Revista De Neurologia
dc.rights Acesso restrito
dc.subject Blood pressure en
dc.subject Endothelial progenitor cells en
dc.subject Hemostasis en
dc.subject Inflammation en
dc.subject Stroke en
dc.subject Statins en
dc.title Statins and stroke: potential mechanisms for neurovascular protection en
dc.title Estatinas y accidente cerebrovascular: posibles mecanismos de acción de la protección neurovascular es
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, BR-04039030 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, BR-04039030 Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000284201500006


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