Statins and stroke: potential mechanisms for neurovascular protection

Statins and stroke: potential mechanisms for neurovascular protection

Title: Statins and stroke: potential mechanisms for neurovascular protection;
Estatinas y accidente cerebrovascular: posibles mecanismos de acción de la protección neurovascular
Author Fonseca, Francisco Antonio Helfenstein Autor UNIFESP Google Scholar
Franca, Carolina Nunes Autor UNIFESP Google Scholar
Póvoa, Rui Manuel dos Santos Autor UNIFESP Google Scholar
Izar, Maria Cristina de Oliveira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract As the average human lifespan is increasing worldwide, ischemic stroke became one of the most important causes of mortality and morbidity, particularly in emerging countries. Significant decrease in the rates of first and recurrent stroke using statins has been established in large clinical trials and in systematic reviews and meta-analyses. Interestingly, observational studies reported that cholesterol levels were only weakly associated with ischemic stroke, suggesting that other potential mechanisms for vascular protection should be implicated. Indeed, beyond lipid changes, some properties of these drugs, related to inflammation, hemostasis, endothelial function, plague stabilization, and more recently, to the mobilization of endothelial cells, have been proposed. In addition, recent meta-analysis also revealed that statins decrease systolic and diastolic blood pressure. Taken together, all these benefits can contribute for stroke prevention by statins.
Keywords Blood pressure
Endothelial progenitor cells
Hemostasis
Inflammation
Stroke
Statins
Language Spanish
Date 2010-11-01
Published in Revista De Neurologia. Barcelona: Revista De Neurologia, v. 51, n. 9, p. 551-560, 2010.
ISSN 0210-0010 (Sherpa/Romeo, impact factor)
Publisher Revista De Neurologia
Extent 551-560
Origin http://www.neurologia.com/sec/resumen.php?or=web&i=e&id=2010430
Access rights Closed access
Type Review
Web of Science ID WOS:000284201500006
URI http://repositorio.unifesp.br/11600/45471

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