Participation of the cholinergic system in the ethanol-induced suppression of paradoxical sleep in rats

Participation of the cholinergic system in the ethanol-induced suppression of paradoxical sleep in rats

Autor Papale, Ligia Assumpção Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Perry, Juliana Cini Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Sleep disturbance is among the many consequences of ethanol abuse in both humans and rodents. Ethanol consumption can reduce REM or paradoxical sleep (PS) in humans and rats, respectively. The first aim of this study was to develop an animal model of ethanol-induced PS suppression. This model administered intragastrically (by gavage) to male Wistar rats (3 months old, 200-250 g) 0.5 to 3.5 g/kg ethanol. The 3.5 g/kg dose of ethanol suppressed the PS stage compared with the vehicle group (distilled water) during the first 2-h interval (0-2 h; 1.3 vs 10.2; P < 0.001). The second aim of this study was to investigate the mechanisms by which ethanol suppresses PS. We examined the effects of cholinergic drug pretreatment. The cholinergic system was chosen because of the involvement of cholinergic neurotransmitters in regulating the sleep-wake cycle. A second set of animals was pretreated with 2.5, 5.0, and 10 mg/kg pilocarpine (cholinergic agonist) or atropine (cholinergic antagonist). These drugs were administered 1 h prior to ethanol (3.5 g/kg) or vehicle. Treatment with atropine prior to vehicle or ethanol produced a statistically significant decrease in PS, whereas pilocarpine had no effect on minutes of PS. Although the mechanism by which ethanol induces PS suppression is not fully understood, these data suggest that the cholinergic system is not the only system involved in this interaction.
Palavra-chave Cholinergic
Atropine
Pilocarpine
Ethanol
Paradoxical sleep
Electroencephalography
Idioma Inglês
Data de publicação 2008-09-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 9, p. 782-788, 2008.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 782-788
Fonte http://dx.doi.org/10.1590/S0100-879X2008000900007
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000259543000003
SciELO S0100-879X2008000900007 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4545

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