Prevalence, risk factors and genetic characterization of human T-cell lymphotropic virus types 1 and 2 in patients infected with human immunodeficiency virus type 1 in the Cities of Ribeirao Preto and Sao Paulo

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dc.contributor.author Kleine Neto, Walter
dc.contributor.author Sanabani, Sabri Saeed [UNIFESP]
dc.contributor.author Jamal, Leda Fatima
dc.contributor.author Sabino, Ester Cerdeira
dc.date.accessioned 2018-06-18T11:48:24Z
dc.date.available 2018-06-18T11:48:24Z
dc.date.issued 2009-05-01
dc.identifier http://dx.doi.org/10.1590/S0037-86822009000300006
dc.identifier.citation Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 42, n. 3, p. 264-270, 2009.
dc.identifier.issn 0037-8682
dc.identifier.uri http://repositorio.unifesp.br/11600/45433
dc.description.abstract The aim of this study was to define the prevalence of human T cell lymphotropic virus types 1 and 2 in patients who were positive for human immunodeficiency virus type 1 in the State of Sao Paulo, Brazil. We evaluated 319 individuals infected with HIV type 1 who were attended at specialized clinics in two cities (Ribeirao Preto and Sao Paulo). The patients were interviewed and tested for antibodies against HTLV types 1 and 2 (Ortho HTLV-1/HTLV-2 Ab-Capture enzyme immunoassay). Direct DNA sequencing of polymerase chain reaction products from the tax region of HTLV type 2 and the long terminal repeat region of HTLV types 1 and 2 were performed to differentiate and determine the subtypes. The overall prevalence of anti-HTLV type 1 and 2 antibodies was 7.5% (24/319; 95% CI: 5.2-11.5). HTLV type 1 and 2 infection was associated with a history of injected drug use and with antibodies for hepatitis C virus (p < 0.001), but not with age (p = 0.2), sex (p = 0.9), sexual behavior or serological markers for sexually transmitted diseases (anti-Treponema pallidum, anti- human herpesvirus type 8 or anti- hepatitis B virus antibodies) (p > 0.05). HTLV DNA was detected in 13 out of 24 samples, of which 12 were characterized as HTLV subtype 2c and one as HTLV subtype 1a. Among the 12 HTLV type 2 samples, seven were from injected drug users, thus indicating that this route is an important risk factor for HTLV type 2 transmission among our population infected with HIV type 1. en
dc.format.extent 264-270
dc.language.iso por
dc.publisher Soc Brasileira Medicina Tropical
dc.relation.ispartof Revista Da Sociedade Brasileira De Medicina Tropical
dc.rights Acesso aberto
dc.subject Human T cell lymphotropic virus type 1 en
dc.subject Human T cell lymphotropic virus type 2 en
dc.subject Prevalence en
dc.subject Risk factors en
dc.subject Human immunodeficiency virus type 1 en
dc.title Prevalence, risk factors and genetic characterization of human T-cell lymphotropic virus types 1 and 2 in patients infected with human immunodeficiency virus type 1 in the Cities of Ribeirao Preto and Sao Paulo en
dc.title Prevalência, fatores de risco e caracterização genética dos vírus linfotrópico de células T humana tipo 1 e 2 em pacientes infectados pelo vírus da imunodeficiência humana tipo 1 nas Cidades de Ribeirão Preto e São Paulo pt
dc.type Artigo
dc.contributor.institution Fundacao Pr6 Sangue
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Secretaria Estado Saude Sao Paulo
dc.description.affiliation Fundacao Pr6 Sangue, Hemoctr Sao Paulo, BR-05403000 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Lab Retrovirol, Dept Doencas Infecciosas & Parasitarias, Sao Paulo, Brazil
dc.description.affiliation Secretaria Estado Saude Sao Paulo, Ctr Referencia & Treinamento DST Aids, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Lab Retrovirol, Dept Doencas Infecciosas & Parasitarias, Sao Paulo, Brazil
dc.identifier.file S0037-86822009000300006.pdf
dc.identifier.scielo S0037-86822009000300006
dc.identifier.doi 10.1590/S0037-86822009000300006
dc.description.source Web of Science
dc.identifier.wos WOS:000269516300006



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