Prevalence, risk factors and genetic characterization of human T-cell lymphotropic virus types 1 and 2 in patients infected with human immunodeficiency virus type 1 in the Cities of Ribeirao Preto and Sao Paulo

Prevalence, risk factors and genetic characterization of human T-cell lymphotropic virus types 1 and 2 in patients infected with human immunodeficiency virus type 1 in the Cities of Ribeirao Preto and Sao Paulo

Title: Prevalence, risk factors and genetic characterization of human T-cell lymphotropic virus types 1 and 2 in patients infected with human immunodeficiency virus type 1 in the Cities of Ribeirao Preto and Sao Paulo;
Prevalência, fatores de risco e caracterização genética dos vírus linfotrópico de células T humana tipo 1 e 2 em pacientes infectados pelo vírus da imunodeficiência humana tipo 1 nas Cidades de Ribeirão Preto e São Paulo
Author Kleine Neto, Walter Google Scholar
Sanabani, Sabri Saeed Autor UNIFESP Google Scholar
Jamal, Leda Fatima Google Scholar
Sabino, Ester Cerdeira Google Scholar
Institution Fundacao Pr6 Sangue
Universidade Federal de São Paulo (UNIFESP)
Secretaria Estado Saude Sao Paulo
Abstract The aim of this study was to define the prevalence of human T cell lymphotropic virus types 1 and 2 in patients who were positive for human immunodeficiency virus type 1 in the State of Sao Paulo, Brazil. We evaluated 319 individuals infected with HIV type 1 who were attended at specialized clinics in two cities (Ribeirao Preto and Sao Paulo). The patients were interviewed and tested for antibodies against HTLV types 1 and 2 (Ortho HTLV-1/HTLV-2 Ab-Capture enzyme immunoassay). Direct DNA sequencing of polymerase chain reaction products from the tax region of HTLV type 2 and the long terminal repeat region of HTLV types 1 and 2 were performed to differentiate and determine the subtypes. The overall prevalence of anti-HTLV type 1 and 2 antibodies was 7.5% (24/319; 95% CI: 5.2-11.5). HTLV type 1 and 2 infection was associated with a history of injected drug use and with antibodies for hepatitis C virus (p < 0.001), but not with age (p = 0.2), sex (p = 0.9), sexual behavior or serological markers for sexually transmitted diseases (anti-Treponema pallidum, anti- human herpesvirus type 8 or anti- hepatitis B virus antibodies) (p > 0.05). HTLV DNA was detected in 13 out of 24 samples, of which 12 were characterized as HTLV subtype 2c and one as HTLV subtype 1a. Among the 12 HTLV type 2 samples, seven were from injected drug users, thus indicating that this route is an important risk factor for HTLV type 2 transmission among our population infected with HIV type 1.
Keywords Human T cell lymphotropic virus type 1
Human T cell lymphotropic virus type 2
Prevalence
Risk factors
Human immunodeficiency virus type 1
Language Portuguese
Date 2009-05-01
Published in Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 42, n. 3, p. 264-270, 2009.
ISSN 0037-8682 (Sherpa/Romeo, impact factor)
Publisher Soc Brasileira Medicina Tropical
Extent 264-270
Origin http://dx.doi.org/10.1590/S0037-86822009000300006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000269516300006
SciELO ID S0037-86822009000300006 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/45433

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