Efeitos da indometacina na inflamaçäo induzida em ratos

Efeitos da indometacina na inflamaçäo induzida em ratos

Alternative title Effects of indomethacin over the experimental inflammation in rats
Author Novo, Neil Ferreira Autor UNIFESP Google Scholar
Santos, Plinio Google Scholar
Simões, Manoel de Jesus Autor UNIFESP Google Scholar
Azevedo, João Luiz Moreira Coutinho Autor UNIFESP Google Scholar
Lapa, Antonio José Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The non-steroidal antiinflamatory agent indomethacin is widely used in the scope of modem surgical practice, where it is known to exert an effect on the inflammatory process. This research aimed to quantify this action using the rat as an experimental model, with the subsequent application of statistical analysis to the results. Both the acute and chronic inflammatory processes were studied. The research showed that the drug indomethacin reduced the development of caraagheenin induced acute inflammation in the rat's paw edema (51 %), and pleurisy fluid (50 %) and cells (58 %). It also reduced chronic inflammation induced via the implantation of cotton pellets into the ra t abdominal wall (64 %). At the celular level, indomethacin was shown to inhibit the growth of foreign body inactive granuloma neutrophils (28 %), macrophages (55 %), fibroblasts (66 %) and the number of collagen fibers (75 %) formed by the presence of a prolypropylene thread at the site of the inflammation. In conclusion, in this study it could be ascertained that the indomethacin was shown to exert a significant inhibitory effect over the inflammatory process as a whole.
Keywords ANTIINFLAMMATORY AGENTS
NONSTEROIDAL
INFLAMMATION
INDOMETHACIN
GRANULOMA
Language Portuguese
Date 1992-06-01
Published in Revista Brasileira De Medicina. Sao Paulo: Moreira Jr Editora Ltda, v. 49, n. 6, p. 287-&, 1992.
ISSN 0034-7264 (Sherpa/Romeo, impact factor)
Publisher Moreira Jr Editora Ltda
Extent 287-&
Access rights Closed access
Type Article
Web of Science ID WOS:A1992JF40900003
URI http://repositorio.unifesp.br/11600/45362

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