Spectral-domain optical coherence tomography imaging of drusenoid pigment epithelial detachments

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dc.contributor.author Garcia Filho, Carlos Alexandre de Amorim [UNIFESP]
dc.contributor.author Yehoshua, Zohar
dc.contributor.author Gregori, Giovanni
dc.contributor.author Farah, Michel Eid [UNIFESP]
dc.contributor.author Feuer, William
dc.contributor.author Rosenfeld, Philip J.
dc.date.accessioned 2018-06-18T11:35:38Z
dc.date.available 2018-06-18T11:35:38Z
dc.date.issued 2013-09-01
dc.identifier http://dx.doi.org/10.1097/IAE.0b013e318285cbd2
dc.identifier.citation Retina-the Journal Of Retinal And Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 8, p. 1558-1566, 2013.
dc.identifier.issn 0275-004X
dc.identifier.uri http://repositorio.unifesp.br/11600/45222
dc.description.abstract Purpose: To evaluate drusenoid retinal pigment epithelial detachments (DPED) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography imaging.Methods: In this prospective natural history study, eyes from patients with the diagnosis of nonexudative AMD and DPEDs were followed for at least 6 months. Eyes were scanned using the Cirrus spectral-domain optical coherence tomography instrument and the 200 x 200 A-scan raster pattern. A custom software was used to quantify volumetric changes in DPEDs and to detect the evolution and formation of geographic atrophy and choroidal neovascularization. Changes in DPED area and volume and development of the advanced forms of AMD were the main outcome.Results: Of the 130 patients (186 eyes) with nonadvanced AMD, 11 patients (16 eyes) presented with DPEDs during the study. Mean follow-up was 18.5 months. Most DPEDs had an area exceeding 1 disk area (14 of 16 eyes) based on color fundus images with a mean area of 4.19 mm(2) (SD = 1.35) measured by spectral-domain optical coherence tomography. The mean volume at the time the DPED was diagnosed was 0.48 mm(3) (SD = 0.28). Four different patterns of progression were observed: DPEDs remained unchanged in 8 of 16 eyes (50%), DPEDs tended to increase in volume before progressing to geographic atrophy in 5 eyes (31.25%) and choroidal neovascularization in 2 eyes (12.5%), and a DPED decreased by more than 50% without progressing to geographic atrophy or choroidal neovascularization in 1 eye (6.25%).Conclusion: Spectral-domain optical coherence tomography imaging is able to detect subtle changes in the area and volume of DPEDs. Quantitative spectral-domain optical coherence tomography imaging of DPEDs is useful for identifying the natural history of disease progression and as a clinical tool for monitoring eyes with AMD in clinical trials. en
dc.description.sponsorship Carl Zeiss Meditec, Inc, Dublin, CA
dc.description.sponsorship Research to Prevent Blindness, Inc
dc.description.sponsorship NEI core center
dc.description.sponsorship Department of Defense (DOD)
dc.description.sponsorship Jerome A. Yavitz Charitable Foundation
dc.description.sponsorship Macula Vision Research Foundation
dc.description.sponsorship Feig Family Foundation
dc.description.sponsorship Gemcon Family Foundation
dc.description.sponsorship Carl and Lily Pforzheimer Foundation
dc.description.sponsorship Emma Clyde Hodge Memorial Foundation
dc.description.sponsorship Carl Zeiss Meditec, Inc.
dc.format.extent 1558-1566
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Retina-the Journal Of Retinal And Vitreous Diseases
dc.rights Acesso restrito
dc.subject spectral-domain optical coherence tomography en
dc.subject SD-OCT en
dc.subject age-related macular degeneration en
dc.subject AMD en
dc.subject retinal pigmented epithelial detachment en
dc.subject PED en
dc.subject drusenoid PED en
dc.title Spectral-domain optical coherence tomography imaging of drusenoid pigment epithelial detachments en
dc.type Artigo
dc.contributor.institution Univ Miami
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Dept Ophthalmol, Miami, FL 33136 USA
dc.description.affiliation Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sponsorshipID NEI core center: P30 EY014801
dc.description.sponsorshipID Department of Defense (DOD): W81XWH-09-1-0675
dc.identifier.doi 10.1097/IAE.0b013e318285cbd2
dc.description.source Web of Science
dc.identifier.wos WOS:000330233200010



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