Spectral-domain optical coherence tomography imaging of drusenoid pigment epithelial detachments

Spectral-domain optical coherence tomography imaging of drusenoid pigment epithelial detachments

Author Garcia Filho, Carlos Alexandre de Amorim Autor UNIFESP Google Scholar
Yehoshua, Zohar Google Scholar
Gregori, Giovanni Google Scholar
Farah, Michel Eid Autor UNIFESP Google Scholar
Feuer, William Google Scholar
Rosenfeld, Philip J. Google Scholar
Institution Univ Miami
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: To evaluate drusenoid retinal pigment epithelial detachments (DPED) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography imaging.Methods: In this prospective natural history study, eyes from patients with the diagnosis of nonexudative AMD and DPEDs were followed for at least 6 months. Eyes were scanned using the Cirrus spectral-domain optical coherence tomography instrument and the 200 x 200 A-scan raster pattern. A custom software was used to quantify volumetric changes in DPEDs and to detect the evolution and formation of geographic atrophy and choroidal neovascularization. Changes in DPED area and volume and development of the advanced forms of AMD were the main outcome.Results: Of the 130 patients (186 eyes) with nonadvanced AMD, 11 patients (16 eyes) presented with DPEDs during the study. Mean follow-up was 18.5 months. Most DPEDs had an area exceeding 1 disk area (14 of 16 eyes) based on color fundus images with a mean area of 4.19 mm(2) (SD = 1.35) measured by spectral-domain optical coherence tomography. The mean volume at the time the DPED was diagnosed was 0.48 mm(3) (SD = 0.28). Four different patterns of progression were observed: DPEDs remained unchanged in 8 of 16 eyes (50%), DPEDs tended to increase in volume before progressing to geographic atrophy in 5 eyes (31.25%) and choroidal neovascularization in 2 eyes (12.5%), and a DPED decreased by more than 50% without progressing to geographic atrophy or choroidal neovascularization in 1 eye (6.25%).Conclusion: Spectral-domain optical coherence tomography imaging is able to detect subtle changes in the area and volume of DPEDs. Quantitative spectral-domain optical coherence tomography imaging of DPEDs is useful for identifying the natural history of disease progression and as a clinical tool for monitoring eyes with AMD in clinical trials.
Keywords spectral-domain optical coherence tomography
age-related macular degeneration
retinal pigmented epithelial detachment
drusenoid PED
Language English
Sponsor Carl Zeiss Meditec, Inc, Dublin, CA
Research to Prevent Blindness, Inc
NEI core center
Department of Defense (DOD)
Jerome A. Yavitz Charitable Foundation
Macula Vision Research Foundation
Feig Family Foundation
Gemcon Family Foundation
Carl and Lily Pforzheimer Foundation
Emma Clyde Hodge Memorial Foundation
Carl Zeiss Meditec, Inc.
Grant number NEI core center: P30 EY014801
Department of Defense (DOD): W81XWH-09-1-0675
Date 2013-09-01
Published in Retina-the Journal Of Retinal And Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 8, p. 1558-1566, 2013.
ISSN 0275-004X (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1558-1566
Origin http://dx.doi.org/10.1097/IAE.0b013e318285cbd2
Access rights Closed access
Type Article
Web of Science ID WOS:000330233200010
URI http://repositorio.unifesp.br/11600/45222

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