Endometrial expression of IL-1RtI in patients undergoing miscarriage or unsuccessful IVF cycles

Show simple item record

dc.contributor.author Haddad-Filho, Jorge [UNIFESP]
dc.contributor.author Cedenho, Agnaldo Pereira [UNIFESP]
dc.contributor.author Katz, Sima Godosevicius [UNIFESP]
dc.date.accessioned 2018-06-18T11:35:33Z
dc.date.available 2018-06-18T11:35:33Z
dc.date.issued 2007-01-01
dc.identifier http://dx.doi.org/10.1016/S1472-6483(10)60773-0
dc.identifier.citation Reproductive Biomedicine Online. Cambridge: Reproductive Healthcare Ltd, v. 14, n. 1, p. 117-124, 2007.
dc.identifier.issn 1472-6483
dc.identifier.uri http://repositorio.unifesp.br/11600/45198
dc.description.abstract This study sought to compare the endometrial expression of interleukin-1 receptor type I in patients with a history of spontaneous recurrent miscarriage and patients with unsuccessful IVF cycles. Eight patients who had undergone two or more consecutive unsuccessful IVF cycles (group I), in which at least one good quality embryo was transferred, and 18 patients with at least three spontaneous late miscarriages (group II) were included in the study. Endometrial and follicular development were evaluated by ultrasonography. Plasma concentrations were evaluated for FSH and prolactin on cycle day 3 and for progesterone on day 7 after ovulation, when an endometrial biopsy was performed; samples were cryopreserved for interleukin-1 receptor type Immunohistochemistry and embedded in paraffin for endometrial dating. Patients with no ovulation or any anomalies in hormone concentrations, uterine cavity or endometrial histology were excluded. Interleukin-1 receptor type I was expressed in the lumenal epithelium of both groups. There was a significant difference (P = 0.0357, two-tailed Fisher's exact test) in the glandular epithelium expression of interleukin-1 receptor type I between groups 1 (87.5% of patients) and II (38.9% of patients). Endometrial expression of interieukin-1 receptor type I does not seem to be involved in embryo implantation in IVF patients, but may play a role in spontaneous recurrent miscarriage. en
dc.format.extent 117-124
dc.language.iso eng
dc.publisher Reproductive Healthcare Ltd
dc.relation.ispartof Reproductive Biomedicine Online
dc.rights Acesso restrito
dc.subject embryonic implantation en
dc.subject human endometrium en
dc.subject interleukin-1 receptor type I en
dc.subject IVF en
dc.subject recurrent miscarriage en
dc.title Endometrial expression of IL-1RtI in patients undergoing miscarriage or unsuccessful IVF cycles en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Sch Med, Dept Histol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Human Reprod Div, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Sch Med, Dept Histol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Human Reprod Div, BR-04023062 Sao Paulo, Brazil
dc.identifier.doi 10.1016/S1472-6483(10)60773-0
dc.description.source Web of Science
dc.identifier.wos WOS:000243506300026



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account