CT and MRI in monitoring response: state-of-the-art and future developments

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dc.contributor.author D'Ippolito, Giuseppe [UNIFESP]
dc.contributor.author Torres, Lucas Rios [UNIFESP]
dc.contributor.author Saito Filho, Celso Fernando [UNIFESP]
dc.contributor.author Ferreira, R. M. [UNIFESP]
dc.date.accessioned 2018-06-18T11:27:23Z
dc.date.available 2018-06-18T11:27:23Z
dc.date.issued 2011-12-01
dc.identifier http://www.minervamedica.it/it/riviste/nuclear-med-molecular-imaging/articolo.php?cod=R39Y2011N06A0603
dc.identifier.citation Quarterly Journal Of Nuclear Medicine And Molecular Imaging. Turin: Edizioni Minerva Medica, v. 55, n. 6, p. 603-619, 2011.
dc.identifier.issn 1824-4785
dc.identifier.uri http://repositorio.unifesp.br/11600/45172
dc.description.abstract The present review is aimed at updating the reader with the current role of computed tomography (CT) and magnetic resonance imaging (MRI) in the evaluation of tumor response, contextualizing the imaging methods advantages and limitations. CT has been the most frequent and widely adopted diagnostic tool. The main advantages of such method include wide availability, high reproducibility, capability to contemporarily evaluate soft tissues, bone and lung parenchyma, besides being easy to perform. Its main limitation is related to the use of ionizing radiation. MRI has emerged as a feasible alternative to CT, particularly in patients with contraindications to the use of iodinated contrast agents, with advantages related to its high soft tissues contrast. The disadvantages are based on its operational complexity and the many technical variables involved which may influence and compromise the reproducibility and broad implementation of the method. New criteria for evaluation of tumor response have recently been proposed, contemplating lately developed drugs and therapeutic strategies that demand the utilization of functional parameters. In this context, the technological developments incorporated in the CT and MRI imaging techniques, such as perfusion analysis, diffusion studies (DW-RM) and MR spectroscopy (MRS), among others, have provided relevant information regarding the tumor response to targeted therapies, anticipating dimensional alterations and guiding physicians in the course of the treatment. Despite such developments, further efforts are needed to establish reproducible protocols, functional response criteria and time intervals for response evaluation in order to allow a definitive incorporation of these new technologies in the assessment of tumor response. en
dc.format.extent 603-619
dc.language.iso eng
dc.publisher Edizioni Minerva Medica
dc.relation.ispartof Quarterly Journal Of Nuclear Medicine And Molecular Imaging
dc.rights Acesso aberto
dc.subject Tomography, X-ray computed en
dc.subject Magnetic resonance imaging en
dc.subject Medical oncology en
dc.title CT and MRI in monitoring response: state-of-the-art and future developments en
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, DDI, Escola Paulista Med, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, DDI, Escola Paulista Med, BR-04024002 Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000301910700003


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