Brazilian flora extracts as source of novel antileishmanial and antifungal compounds

Brazilian flora extracts as source of novel antileishmanial and antifungal compounds

Author Tempone, André Gustavo Google Scholar
Sartorelli, Patricia Autor UNIFESP Google Scholar
Teixeira, Denise Google Scholar
Prado, Frederico O Google Scholar
Calixto, Ivete Arl Google Scholar
Lorenzi, Harri Google Scholar
Melhem, Márcia Sc Google Scholar
Institution Instituto Adolfo Lutz Serviço de Parasitologia Laboratório de Toxinologia Aplicada
Universidade Federal de São Paulo (UNIFESP)
Instituto Plantarum de Estudos da Flora
Abstract Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a protozoan parasitic disease found mainly in developing countries, and it has toxic therapies with few alternatives. Fungal infections have been the main cause of death in immunocompromised patients and new drugs are urgently needed. In this work, a total of 16 plant species belonging to 11 families, selected on an ethnopharmacological basis, were analyzed in vitro against Leishmania (L.) chagasi, Leishmania (L.) amazonensis, Candida krusei, and C. parapsilosis. Of these plant species, seven showed antifungal activity against C. krusei, five showed antileishmanial activity against L. chagasi and four against L. amazonensis, among them species of genus Plectranthus. Our findings confirm the traditional therapeutic use of these plants in the treatment of infectious and inflammatory disorders and also offer insights into the isolation of active and novel drug prototypes, especially those used against neglected diseases as Leishmaniasis.
Keywords Leishmania
Candida
plants
antimicrobial
drugs
therapy
Language English
Date 2008-08-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 103, n. 5, p. 443-449, 2008.
ISSN 0074-0276 (Sherpa/Romeo)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 443-449
Origin http://dx.doi.org/10.1590/S0074-02762008000500006
Access rights Open access Open Access
Type Article
SciELO ID S0074-02762008000500006 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/4516

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