Brazilian flora extracts as source of novel antileishmanial and antifungal compounds

Brazilian flora extracts as source of novel antileishmanial and antifungal compounds

Autor Tempone, André Gustavo Google Scholar
Sartorelli, Patricia Autor UNIFESP Google Scholar
Teixeira, Denise Google Scholar
Prado, Frederico O Google Scholar
Calixto, Ivete Arl Google Scholar
Lorenzi, Harri Google Scholar
Melhem, Márcia Sc Google Scholar
Instituição Instituto Adolfo Lutz Serviço de Parasitologia Laboratório de Toxinologia Aplicada
Universidade Federal de São Paulo (UNIFESP)
Instituto Plantarum de Estudos da Flora
Resumo Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a protozoan parasitic disease found mainly in developing countries, and it has toxic therapies with few alternatives. Fungal infections have been the main cause of death in immunocompromised patients and new drugs are urgently needed. In this work, a total of 16 plant species belonging to 11 families, selected on an ethnopharmacological basis, were analyzed in vitro against Leishmania (L.) chagasi, Leishmania (L.) amazonensis, Candida krusei, and C. parapsilosis. Of these plant species, seven showed antifungal activity against C. krusei, five showed antileishmanial activity against L. chagasi and four against L. amazonensis, among them species of genus Plectranthus. Our findings confirm the traditional therapeutic use of these plants in the treatment of infectious and inflammatory disorders and also offer insights into the isolation of active and novel drug prototypes, especially those used against neglected diseases as Leishmaniasis.
Palavra-chave Leishmania
Candida
plants
antimicrobial
drugs
therapy
Idioma Inglês
Data de publicação 2008-08-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 103, n. 5, p. 443-449, 2008.
ISSN 0074-0276 (Sherpa/Romeo)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 443-449
Fonte http://dx.doi.org/10.1590/S0074-02762008000500006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0074-02762008000500006 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4516

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