The papain pocket delivery impairs the capsule fibrous healing around textured silicone implants in rats.

Show simple item record

dc.contributor.author Moreira, Marcio [UNIFESP]
dc.contributor.author Fagundes, Djalma Jose [UNIFESP]
dc.contributor.author Long, Charles A.
dc.contributor.author Anninos, Photios
dc.contributor.author Pham, Tuan
dc.contributor.author Anastassopoulos, George
dc.contributor.author Mastorakis, Nikos E.
dc.date.accessioned 2018-06-18T11:27:12Z
dc.date.available 2018-06-18T11:27:12Z
dc.date.issued 2009-01-01
dc.identifier http://www.wseas.us/e-library/conferences/2009/moscow/BEBI/BEBI24.pdf?CFID=717212942&CFTOKEN=29430700
dc.identifier.citation Proceedings Of The 2nd Wseas International Conference On Biomedical Electronics And Biomedical Informatics. Athens: World Scientific And Engineering Acad And Soc, p. 148-153, 2009.
dc.identifier.issn 1790-5125
dc.identifier.uri http://repositorio.unifesp.br/11600/45130
dc.description.abstract To study the tissue repair around the textured mammary implants under the action of papain (PA). Methods: Thirty-six Wistar rats were evaluated and randomly distributed into two groups (n = 18): papain (PA) and control (CT). Each group was equally distributed into 3 subgroups (n = 6) and observed on seventh, thirtieth-fifth and ninth pos-operative days. Each animal received a textured implant in the left dorso-axillary region (sham - SH), on were instilled 0.5 mL saline solution 0.9%, and another textured implant on the right dorso-axillary region (papain - PA), on were instilled 0.5 mL of water-soluble solution of papain. The control group (CT) received only textured implant in the left dorso-axillary region with prior instillation of 0.5 mL of saline solution 0.9%. The histological analysis of the 3 subgroups was carried out using picrosirius-red stain and an image analyzing system using the Image Pro Plus (TM) program to evaluate the thickness and maturation and deposition of collagen fibers. Immunohistochemical evaluation was performed, using micrometric reticules of Weiss (Olympus Labstore (TM)), for myofibroblasts counting only in the 90(th) day subgroup. Results: At 35(th) and 90(th) days, the papain group (PA) presented reduction on the fibrous capsule thickness around the implant, in the number of collagen fibers and myofibroblasts, comparing to the control group (CT). Conclusion: The papain drug decreased the fibrous capsule formation around the textured silicon implants in rats. en
dc.format.extent 148-153
dc.language.iso eng
dc.publisher World Scientific And Engineering Acad And Soc
dc.relation.ispartof Proceedings Of The 2nd Wseas International Conference On Biomedical Electronics And Biomedical Informatics
dc.rights Acesso aberto
dc.subject Mammary implant en
dc.subject capsular contracture en
dc.subject inflammation en
dc.subject capsular thickness en
dc.title The papain pocket delivery impairs the capsule fibrous healing around textured silicone implants in rats. en
dc.type Trabalho apresentado em evento
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Dept Surg, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Surg, BR-04023900 Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000273246200024



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account