The papain pocket delivery impairs the capsule fibrous healing around textured silicone implants in rats.

The papain pocket delivery impairs the capsule fibrous healing around textured silicone implants in rats.

Author Moreira, Marcio Autor UNIFESP Google Scholar
Fagundes, Djalma Jose Autor UNIFESP Google Scholar
Long, Charles A. Google Scholar
Anninos, Photios Google Scholar
Pham, Tuan Google Scholar
Anastassopoulos, George Google Scholar
Mastorakis, Nikos E. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract To study the tissue repair around the textured mammary implants under the action of papain (PA). Methods: Thirty-six Wistar rats were evaluated and randomly distributed into two groups (n = 18): papain (PA) and control (CT). Each group was equally distributed into 3 subgroups (n = 6) and observed on seventh, thirtieth-fifth and ninth pos-operative days. Each animal received a textured implant in the left dorso-axillary region (sham - SH), on were instilled 0.5 mL saline solution 0.9%, and another textured implant on the right dorso-axillary region (papain - PA), on were instilled 0.5 mL of water-soluble solution of papain. The control group (CT) received only textured implant in the left dorso-axillary region with prior instillation of 0.5 mL of saline solution 0.9%. The histological analysis of the 3 subgroups was carried out using picrosirius-red stain and an image analyzing system using the Image Pro Plus (TM) program to evaluate the thickness and maturation and deposition of collagen fibers. Immunohistochemical evaluation was performed, using micrometric reticules of Weiss (Olympus Labstore (TM)), for myofibroblasts counting only in the 90(th) day subgroup. Results: At 35(th) and 90(th) days, the papain group (PA) presented reduction on the fibrous capsule thickness around the implant, in the number of collagen fibers and myofibroblasts, comparing to the control group (CT). Conclusion: The papain drug decreased the fibrous capsule formation around the textured silicon implants in rats.
Keywords Mammary implant
capsular contracture
inflammation
capsular thickness
Language English
Date 2009-01-01
Published in Proceedings Of The 2nd Wseas International Conference On Biomedical Electronics And Biomedical Informatics. Athens: World Scientific And Engineering Acad And Soc, p. 148-153, 2009.
ISSN 1790-5125 (Sherpa/Romeo, impact factor)
Publisher World Scientific And Engineering Acad And Soc
Extent 148-153
Origin http://www.wseas.us/e-library/conferences/2009/moscow/BEBI/BEBI24.pdf?CFID=717212942&CFTOKEN=29430700
Access rights Open access Open Access
Type Conference paper
Web of Science ID WOS:000273246200024
URI http://repositorio.unifesp.br/11600/45130

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