Lipid metabolism of monosodium glutamate obese rats after partial removal of adipose tissue

Lipid metabolism of monosodium glutamate obese rats after partial removal of adipose tissue

Author Bueno, Allain Amador Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Estadella, Debora Autor UNIFESP Google Scholar
Habitante, Carlos Alexandre Autor UNIFESP Google Scholar
Bernardes, Bruno Sérgio de Souza Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We analyzed the effects of partial fat pad removal on retroperitoneal and epididymal fat depots and carcass metabolism of control (C) and MSG-obese (M) rats. Three-month-old C and M male Wistar rats were submitted to either partial surgical excision of epididymal and retroperitoneal fat tissue (lipectomy, Q or sham surgery (S) and studied after 7 or 30 days. Retroperitoneal and epididymal tissue re-growth after lipectomy was not observed, as indicated by the low pads weight of the L groups. The lipolysis rate was stimulated in LC7 and LM7, probably due to surgical stress and low insulin levels. In LM7, but not in LC7, in vivo lipogenesis rate increased in retroperitoneal and epididymal fat tissue, as did the diet-derived lipid accumulation in epididymal fat tissue. Although these local increases were no longer present in LM30, this group showed a large increase in the percentage of small area adipocytes in both pads as well as increased carcass lipogenesis rate. The present data showed that the partial removal of fat depots affected the metabolism of control and MSG-obese rats differently. In the obese animals only, it stimulated both local and carcass lipogenesis rate as well as adipocyte differentiation, i.e. responses likely to favor excised tissue re-growth and/or compensatory growth of non-excised depots.
Keywords lipectomy
MSG rats
adipocyte area
lipogenesis rate
lipolysis rate
Language English
Date 2005-01-01
Published in Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 54, n. 1, p. 57-65, 2005.
ISSN 0862-8408 (Sherpa/Romeo, impact factor)
Publisher Acad Sciences Czech Republic, Inst Physiology
Extent 57-65
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000227607100007

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