Systemic vasculitis in myelodysplastic syndromes

Systemic vasculitis in myelodysplastic syndromes

Author Oostvogels, Rimke Google Scholar
Petersen, Elijah Joel Google Scholar
Chauffaille, Maria de Lourdes Lopes Ferrari Autor UNIFESP Google Scholar
Abrahams, Alferso C. Google Scholar
Institution Univ Med Ctr Utrecht
Universidade Federal de São Paulo (UNIFESP)
Abstract The development of immunological abnormalities in various neoplasms is a rather common phenomenon. The prevalence of life-threatening systemic vasculitis in malignancy, however, is much lower. Nonetheless we found an unexpected frequency of several autoimmune manifestations, including systemic vasculitis, in certain myelodysplastic syndromes.We illustrate this finding with the case of a 43-year-old man with signs of polyarteritis nodosa-like systemic vasculitis during progression of chronic myelomonocytic leukaemia. Subsequently, we review the literature on the combination of myelodysplastic syndromes and systemic vasculitis and discuss the prognostic consequences, considerations for treatment and possible pathophysiological mechanisms.
Keywords Chronic myelomonocytic leukaemia
myelodysplastic syndromes
polyarteritis nodosa
Language English
Date 2012-02-01
Published in Netherlands Journal Of Medicine. Alphen Aan De Rijn: Van Zuiden Communications, v. 70, n. 2, p. 63-68, 2012.
ISSN 0300-2977 (Sherpa/Romeo, impact factor)
Publisher Van Zuiden Communications
Extent 63-68
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000308204600003

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