The enteroinsular axis and endocrine pancreatic function in chronic alcohol consumers: evidence for early beta-cell hypofunction

The enteroinsular axis and endocrine pancreatic function in chronic alcohol consumers: evidence for early beta-cell hypofunction

Author Patto, Renato de Jesus Autor UNIFESP Google Scholar
Russo, Ewaldo Mario Kuhlmann Google Scholar
Borges, Durval Rosa Autor UNIFESP Google Scholar
Neves, Manoel Martins das Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
FAC MED TRIANGULO MINEIRO
Abstract Chronic alcohol consumers may have, as judged by functional criteria, exocrine as well as endocrine pancreatic dysfunction, the latter represented by a decreased insulin response to an oral glucose load. To investigate whether this decreased insulin response was due to an ethanol-induced beta-cell dysfunction or to an ethanol-induced dysfunction of the enteroinsular axis, we determined glucose, insulin, and C-peptide plasma concentrations following an oral and an intravenous glucose load in 16 healthy volunteer nonalcohol consumers and in 10 chronic alcohol consumers. In each group, total integrated response for glucose did not significantly change whether glucose was given orally or intravenously, indicating isoglycemic glucose loads. The total integrated response values for insulin in the alcoholic group following both glucose loads as well as C-peptide plasma concentrations were significantly lower than in the control group. Moreover, in both groups the insulin TIR values following the oral glucose load were significantly greater than the values obtained following the intravenous glucose load, indicating an incretin effect. These results indicate that the decreased insulin response observed in alcoholics was not caused by a dysfunction of the enteroinsular axis because it also occurred following an intravenous glucose load, but by an ethanol-induced beta-cell dysfunction because C-peptide and insulin were proportionally decreased in this group.
Language English
Date 1993-09-01
Published in Mount Sinai Journal Of Medicine. New York: Mount Sinai Hospital, v. 60, n. 4, p. 317-320, 1993.
ISSN 0027-2507 (Sherpa/Romeo, impact factor)
Publisher Mount Sinai Hospital
Extent 317-320
Access rights Closed access
Type Article
Web of Science ID WOS:A1993LX33600012
URI http://repositorio.unifesp.br/11600/44941

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