Strategies for Development of Antimalarials Based on Encapsulated Porphyrin Derivatives

Strategies for Development of Antimalarials Based on Encapsulated Porphyrin Derivatives

Author Deda, Daiana Kotra Google Scholar
Budu, Alexandre Autor UNIFESP Google Scholar
Cruz, Laura Nogueira Google Scholar
Araki, Koiti Google Scholar
Garcia, Celia Regina da Silva Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Despite the efforts in controlling the parasite and infection, and the significant progress achieved in recent years in its treatment, malaria is still prevalent in many regions and out of control in others. The repertoire of alternatives to fight malaria is being expanded, not only by designing new drugs but also by developing improved drug delivery systems able to enhance the antimalarial efficiency of conventional and new drugs. Among the new drugs that have been investigated, several publications report the use of porphyrin derivatives as antimalarials but their efficiency is contradictory. The low activity of porphyrins seems to be associated with low dispersibility and bioavailability. In this respect, Nanotechnology can provide efficient solutions to enhance bioavailability and delivery of conventional and new antimalarials, in order to assure high enough efficiency levels to inactivate the parasite. Thus, in this review we highlight the use of drug delivery systems for conventional and new antimalarials and we propose the encapsulation of porphyrins as a promising alternative for development of anti-malarial formulations.
Keywords Drug delivery systems
Plasmodium falciparum
polymeric particles
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2014-01-01
Published in Mini-reviews In Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 14, n. 13, p. 1055-1071, 2014.
ISSN 1389-5575 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 1055-1071
Access rights Closed access
Type Review
Web of Science ID WOS:000347919000004

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