Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice

Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice

Author Rodrigues, Mauricio Martins Autor UNIFESP Google Scholar
Alencar, Bruna Cunha Gondim de Autor UNIFESP Google Scholar
Claser, Carla Autor UNIFESP Google Scholar
Tzelepis, Fanny Autor UNIFESP Google Scholar
Silveira, Eduardo Lani Volpe da Autor UNIFESP Google Scholar
Haolla, Filipe Augusto Bettencourt Autor UNIFESP Google Scholar
Dominguez, Mariana Ribeiro Autor UNIFESP Google Scholar
Vasconcelos, Jose Ronnie Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Vaccines have had an unquestionable impact on public health during the last century. The most likely reason for the success of vaccines is the robust protective properties of specific antibodies. However, antibodies exert a strong selective pressure and many microorganisms, such as the obligatory intracellular parasite Trypanosoma cruzi, have been selected to survive in their presence. Although the host develops a strong immune response to T. cruzi, they do not clear the infection and instead progress to the chronic phase of the disease. Parasite persistence during the chronic phase of infection is now considered the main factor contributing to the chronic symptoms of the disease. Based on this finding, containment of parasite growth and survival may be one method to avoid the immunopathology of the chronic phase. In this context, vaccinologists have looked over the past 20 years for other immune effector mechanisms that could eliminate these antibody-resistant pathogens. We and others have tested the hypothesis that non-antibody-mediated cellular immune responses (CD4(+) Th1 and CD8(+) Tc1 cells) to specific parasite antigens/genes expressed by T. cruzi could indeed be used for the purpose of vaccination. This hypothesis was confirmed in different mouse models, indicating a possible path for vaccine development.
Keywords Trypanosoma cruzi
vaccine
immunity
Language English
Date 2009-07-01
Published in Memorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 104, n. S1, p. 281-287, 2009.
ISSN 0074-0276 (Sherpa/Romeo, impact factor)
Publisher Fundaco Oswaldo Cruz
Extent 281-287
Origin http://dx.doi.org/10.1590/S0074-02762009000900037
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000269123500036
SciELO ID S0074-02762009000900037 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/44890

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