Quantitation of the soluble E-receptor of human T lymphocytes by rocket electrophoresis in the serum of patients with lepromatous and tuberculoid leprosy

Quantitation of the soluble E-receptor of human T lymphocytes by rocket electrophoresis in the serum of patients with lepromatous and tuberculoid leprosy

Author Longo-Maugéri, Ieda Maria Autor UNIFESP Google Scholar
Moura, N. C. Autor UNIFESP Google Scholar
Opromolla, Diltor Vladimir Araujo Autor UNIFESP Google Scholar
Mendes, Nelson Figueiredo Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Human T lymphocytes carry a membrane receptor for sheep erythrocytes (E) which is responsible for the well-known phenomenon of E-rosette formation. This receptor has been related to CD2 molecules; it is present in a soluble form (Rs) in normal serum and may play an immunoregulatory role. In this study we quantitated soluble E-receptor in serum samples of 43 normal controls, 32 patients with tuberculoid leprosy and 53 with lepromatous leprosy, using rocket electrophoresis and an anti E receptor serum (anti-Rs) obtained from an adult sheep immunized with autologous E treated with Rs. In the 3 groups studied, the rocket means were respectively 5.0, 7.5 and 10.9 mm (p < 0.001). We found abnormally high levels of Rs in the serum of various diseases associated with a depression of cell-mediated immunity. The increase of Rs levels in the serum may be one of the mechanisms responsible for the depression of cellular immunity in leprosy.
Language English
Date 1991-01-01
Published in Medicina-buenos Aires. Buenos Aires: Medicina (buenos Aires), v. 51, n. 2, p. 133-136, 1991.
ISSN 0025-7680 (Sherpa/Romeo, impact factor)
Publisher Medicina (buenos Aires)
Extent 133-136
Access rights Closed access
Type Article
Web of Science ID WOS:A1991FU04100006
URI http://repositorio.unifesp.br/11600/44884

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