Sustained Virological Response to Treatment of Chronic Hepatitis C in Midwest, Brazil

Sustained Virological Response to Treatment of Chronic Hepatitis C in Midwest, Brazil

Author Scariott, Mirian Google Scholar
Oliveira, Sandra Maria do Valle Leone de Google Scholar
Matos, Vanessa Terezinha Gubert de Google Scholar
Uehara, Silvia Naomi de Oliveira Autor UNIFESP Google Scholar
Paniago, Anamaria Mello Miranda Google Scholar
Institution Universidade Federal de Mato Grosso do Sul (UFMS)
Universidade Federal de São Paulo (UNIFESP)
Abstract The purpose of the study was to present the differences in outcomes between the treatments of patients with chronic hepatitis C who attended the Hepatitis Referral Service of the state of Mato Grosso do Sul, Midwest region, Brazil, in the era of dual therapy. The medical records of 82 patients were reviewed and 92 treatments were observed in the study period. The sustained virological response (SVR) rate was 44.0% in patients treated with pegylated interferon alpha (PEG-INF) plus ribavirin (REV) and it was 58.8% in patients treated with conventional interferon alpha (INF-c) plus REV (p = 0.268). The SVR is associated with PEG-INF use (p = 0.004), viral load < 850,000 IU/mL, (p = 0.015), normal values of alanine and aspartate aminotransferases (p < 0.001), bilirubin (p = 0.002) and glucose (p = 0.031). SRV rate was reduced in patients who develop anemia (p = 0.033). The treatment generally does not favor more than 50% of chronic hepatitis C carriers and many patients did not return to the referral service after the end of treatment.
Keywords Conventional interferon
Hepatitis C virus
Pegylated interferon
Sustained virological response
Treatment
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2014-03-01
Published in Latin American Journal Of Pharmacy. La Plata: Colegio Farmaceuticos Provincia De Buenos Aires, v. 33, n. 2, p. 204-209, 2014.
ISSN 0326-2383 (Sherpa/Romeo, impact factor)
Publisher Colegio Farmaceuticos Provincia De Buenos Aires
Extent 204-209
Origin http://www.latamjpharm.org/resumenes/33/2/LAJOP_33_2_1_4.pdf
Access rights Closed access
Type Article
Web of Science ID WOS:000337935800004
URI http://repositorio.unifesp.br/11600/44850

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