Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010

Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010

Author Salomon, Joshua A. Google Scholar
Vos, Theo Google Scholar
Hogan, Daniel R. Google Scholar
Gagnon, Michael Google Scholar
Naghavi, Mohsen Google Scholar
Mokdad, Ali Google Scholar
Begum, Nazma Google Scholar
Shah, Razibuzzaman Google Scholar
Karyana, Muhammad Google Scholar
Kosen, Soewarta Google Scholar
Farje, Mario Reyna Google Scholar
Moncada, Gilberto Google Scholar
Dutta, Arup Google Scholar
Sazawal, Sunil Google Scholar
Dyer, Andrew Google Scholar
Seiler, Jason Google Scholar
Aboyans, Victor Google Scholar
Baker, Lesley Google Scholar
Baxter, Amanda Google Scholar
Benjamin, Emelia J. Google Scholar
Bhalla, Kavi Google Scholar
Bin Abdulhak, Aref Google Scholar
Blyth, Fiona Google Scholar
Bourne, Rupert Google Scholar
Braithwaite, Tasanee Google Scholar
Brooks, Peter Google Scholar
Brugha, Traolach S. Google Scholar
Bryan-Hancock, Claire Google Scholar
Buchbinder, Rachelle Google Scholar
Burney, Peter Google Scholar
Calabria, Bianca Google Scholar
Chen, Honglei Google Scholar
Chugh, Sumeet S. Google Scholar
Cooley, Rebecca Google Scholar
Criqui, Michael H. Google Scholar
Cross, Marita Google Scholar
Dabhadkar, Kaustubh C. Google Scholar
Dahodwala, Nabila Google Scholar
Davis, Adrian Google Scholar
Degenhardt, Louisa Google Scholar
Diaz-Torne, Cesar Google Scholar
Dorsey, E. Ray Google Scholar
Driscoll, Tim Google Scholar
Edmond, Karen Google Scholar
Elbaz, Alexis Google Scholar
Ezzati, Majid Google Scholar
Feigin, Valery Google Scholar
Ferri, Cleusa Pinheiro Autor UNIFESP Google Scholar
Flaxman, Abraham D. Google Scholar
Flood, Louise Google Scholar
Fransen, Marlene Google Scholar
Fuse, Kana Google Scholar
Gabbe, Belinda J. Google Scholar
Gillum, Richard F. Google Scholar
Haagsma, Juanita Google Scholar
Harrison, James E. Google Scholar
Havmoeller, Rasmus Google Scholar
Hay, Roderick J. Google Scholar
Hel-Baqui, Abdullah Google Scholar
Hoek, Hans W. Google Scholar
Hoffman, Howard Google Scholar
Hogeland, Emily Google Scholar
Hoy, Damian Google Scholar
Jarvis, Deborah Google Scholar
Karthikeyan, Ganesan Google Scholar
Knowlton, Lisa Marie Google Scholar
Lathlean, Tim Google Scholar
Leasher, Janet L. Google Scholar
Lim, Stephen S. Google Scholar
Lipshultz, Steven E. Google Scholar
Lopez, Alan D. Google Scholar
Lozano, Rafael Google Scholar
Lyons, Ronan Google Scholar
Malekzadeh, Reza Google Scholar
Marcenes, Wagner Google Scholar
March, Lyn Google Scholar
Margolis, David J. Google Scholar
McGill, Neil Google Scholar
McGrath, John Google Scholar
Mensah, George A. Google Scholar
Meyer, Ana-Claire Google Scholar
Michaud, Catherine Google Scholar
Moran, Andrew Google Scholar
Mori, Rintaro Google Scholar
Murdoch, Michele E. Google Scholar
Naldi, Luigi Google Scholar
Newton, Charles R. Google Scholar
Norman, Rosana Google Scholar
Omer, Saad B. Google Scholar
Osborne, Richard Google Scholar
Pearce, Neil Google Scholar
Perez-Ruiz, Fernando Google Scholar
Perico, Norberto Google Scholar
Pesudovs, Konrad Google Scholar
Phillips, David Google Scholar
Pourmalek, Farshad Google Scholar
Prince, Martin Google Scholar
Rehm, Juergen T. Google Scholar
Remuzzi, Guiseppe Google Scholar
Richardson, Kathryn Google Scholar
Room, Robin Google Scholar
Saha, Sukanta Google Scholar
Sampson, Uchechukwu Google Scholar
Sanchez-Riera, Lidia Google Scholar
Segui-Gomez, Maria Google Scholar
Shahraz, Saeid Google Scholar
Shibuya, Kenji Google Scholar
Singh, David Google Scholar
Sliwa, Karen Google Scholar
Smith, Emma Google Scholar
Soerjomataram, Isabelle Google Scholar
Steiner, Timothy Google Scholar
Stolk, Wilma A. Google Scholar
Stovner, Lars Jacob Google Scholar
Sudfeld, Christopher Google Scholar
Taylor, Hugh R. Google Scholar
Tleyjeh, Imad M. Google Scholar
van der Werf, Marieke J. Google Scholar
Watson, Wendy L. Google Scholar
Weatherall, David J. Google Scholar
Weintraub, Robert Google Scholar
Weisskopf, Marc G. Google Scholar
Whiteford, Harvey Google Scholar
Wilkinson, James D. Google Scholar
Woolf, Anthony D. Google Scholar
Zheng, Zhi-Jie Google Scholar
Murray, Christopher J. L. Google Scholar
Institution Harvard Univ
Univ Queensland
Univ Washington
Projahnmo Shimantik
Minist Hlth
Inst Cuanto
Johns Hopkins Univ
Dupuytren Univ Hosp
Boston Univ
King Fahad Med City
Univ Sydney
Anglia Ruskin Univ
Moorfields Eye Hosp
Univ Leicester
Flinders Univ S Australia
Monash Univ
Cabrini Inst
Univ London Imperial Coll Sci Technol & Med
Univ New S Wales
Cedars Sinai Med Ctr
Univ Calif San Diego
Emory Univ
Univ Penn
MRC Hearing & Commun Grp
Hosp Santa Creu & St Pablo
London Sch Hyg & Trop Med
MRC HPA Ctr Environm & Hlth
Auckland Univ Technol
Universidade Federal de São Paulo (UNIFESP)
Natl Inst Populat & Social Secur Res
Howard Univ
Univ Med Ctr Rotterdam
Kings Coll Hosp NHS Fdn Trust
Kings Coll London
Karolinska Univ Hosp
Parnassia Psychiat Inst
Univ Calif San Francisco
All India Inst Med Sci
Nova SE Univ
Univ Miami
Swansea Univ
Univ Tehran Med Sci
Queen Mary Univ London
Univ Cape Town
China Med Board
Columbia Univ
Natl Ctr Child Hlth & Dev
Watford Dist Gen Hosp
Centro Studi GISED
Univ Oxford
Deakin Univ
Hosp Univ Cruces
Mario Negri Inst Pharmacol Res
Univ British Columbia
Ctr Addict & Mental Hlth
Turning Point Alcohol & Drug Ctr
Univ Cambridge
Vanderbilt Univ
Inst Invest Biomed Bellvitge
Govt Spain
Brandeis Univ
Univ Tokyo
Queens Med Ctr
Norwegian Univ Sci & Technol
Murdoch Childrens Res Inst
Royal Cornwall Hosp
Shanghai Jiao Tong Univ
Abstract Background Measurement of the global burden of disease with disability-adjusted life-years (DALYs) requires disability weights that quantify health losses for all non-fatal consequences of disease and injury. There has been extensive debate about a range of conceptual and methodological issues concerning the definition and measurement of these weights. Our primary objective was a comprehensive re-estimation of disability weights for the Global Burden of Disease Study 2010 through a large-scale empirical investigation in which judgments about health losses associated with many causes of disease and injury were elicited from the general public in diverse communities through a new, standardised approach.Methods We surveyed respondents in two ways: household surveys of adults aged 18 years or older (face-to-face interviews in Bangladesh, Indonesia, Peru, and Tanzania; telephone interviews in the USA) between Oct 28, 2009, and June 23, 2010; and an open-access web-based survey between July 26, 2010, and May 16, 2011. The surveys used paired comparison questions, in which respondents considered two hypothetical individuals with different, randomly selected health states and indicated which person they regarded as healthier. The web survey added questions about population health equivalence, which compared the overall health benefits of different life-saving or disease-prevention programmes. We analysed paired comparison responses with probit regression analysis on all 220 unique states in the study. We used results from the population health equivalence responses to anchor the results from the paired comparisons on the disability weight scale from 0 (implying no loss of health) to 1 (implying a health loss equivalent to death). Additionally, we compared new disability weights with those used in WHO's most recent update of the Global Burden of Disease Study for 2004.Findings 13 902 individuals participated in household surveys and 16 328 in the web survey. Analysis of paired comparison responses indicated a high degree of consistency across surveys: correlations between individual survey results and results from analysis of the pooled dataset were 0.9 or higher in all surveys except in Bangladesh (r=0.75). Most of the 220 disability weights were located on the mild end of the severity scale, with 58 (26%) having weights below 0.05. Five (11%) states had weights below 0.01, such as mild anaemia, mild hearing or vision loss, and secondary infertility. The health states with the highest disability weights were acute schizophrenia (0.76) and severe multiple sclerosis (0.71). We identified a broad pattern of agreement between the old and new weights (r=0.70), particularly in the moderate-to-severe range. However, in the mild range below 0.2, many states had significantly lower weights in our study than previously.Interpretation This study represents the most extensive empirical effort as yet to measure disability weights. By contrast with the popular hypothesis that disability assessments vary widely across samples with different cultural environments, we have reported strong evidence of highly consistent results.
Language English
Sponsor Spanish Health Ministry
Hospital de Cruces Rheumatology Association
Burke Global Health Fellowship Program at the Harvard Global Health Institute
World Bank Global Road Safety Facility
Vision and Eye Research Unit (Postgraduate Medical Institute, Anglia Ruskin University, Cambridge, UK)
Department of Health London for the National Health Service Information Centre
University of Leicester for the Estimating the Prevalence of Autism Spectrum Conditions in Adults
Bill & Melinda Gates Foundation
Australian National Health and Medical Research Council (NHMRC)
Monash University
Cabrini Health
BUPA Foundation
National Institutes of Health (NIH)-the National Institute of Environmental Health Sciences-USA
Royal North Shore Hospital
Institute of Bone and Joint Research, (University of Sydney)
Parkinson Council
Safework Australia
Swedish Research Council
Parnassia Psychiatric Institute, The Hague, Netherlands
Department of Psychiatry, University Medical Center Groningen, Netherlands
Department of Epidemiology, Columbia University, New York, NY, USA
Australian National Health and Medical Research Council
Foundation for Alcohol Research and Education
Victorian Department of Health
Harold Amos Medical Faculty Development Award of the Robert Wood Johnson Foundation
Vanderbilt Clinical and Translational Scholars Award
European Center for Injury Prevention, Universidad de Navarra
Africa Programme for Onchocerciasis Control (WHO/APOC)
Wellcome Trust UK
Medical Research Council UK
Anthony Cerami and Ann Dunne Research Trust
Grant number NIH: K23 AG034236
Swedish Research Council: 2011-1071
Date 2012-12-15
Published in Lancet. New York: Elsevier Science Inc, v. 380, n. 9859, p. 2129-2143, 2012.
ISSN 0140-6736 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2129-2143
Access rights Closed access
Type Article
Web of Science ID WOS:000312387000013

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account