Apoptosis of leukocytes: Basic concepts and implications in uremia

Apoptosis of leukocytes: Basic concepts and implications in uremia

Author Jaber, Bertrand L. Autor UNIFESP Google Scholar
Cendoroglo Neto, Miguel Autor UNIFESP Google Scholar
Balakrishnan, Vaidyanathapuram S. Google Scholar
Perianayagam, Mary C. Google Scholar
King, Andrew J. Google Scholar
Pereira, Brian JG Google Scholar
Institution Univ Fed Ceara
Hosp Clin Montevideo
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal Fluminense (UFF)
Abstract Circulating blood leukocytes have short life expectancies and end their lives by committing programmed cell death or apoptosis. Apoptosis is an active form of cell death that is initiated by a number of stimuli and is intricately regulated. Apoptosis in both excessive and reduced amounts has pathological implications. Evidence suggests that apoptosis may play a role in the pathophysiology of immune dysfunction in uremia. Indeed, accelerated programmed cell death has been observed in lymphocytes, monocytes, and polymorphonuclear leukocytes among patients with chronic renal failure. This may be due in part to the retention of uremic toxins. The aim of this article is to review the evidence for accelerated leukocyte apoptosis, key regulatory apoptotic pathways, and the possible role of this highly organized process in the pathogenesis of immune dysfunction in uremia.
Keywords cell death
Language English
Date 2001-02-01
Published in Kidney International. Malden: Blackwell Science Inc, v. 59, n. supl 78, p. S197-S205, 2001.
ISSN 0085-2538 (Sherpa/Romeo, impact factor)
Publisher Blackwell Science Inc
Extent S54-S56
Origin http://dx.doi.org/10.1046/j.1523-1755.2001.59780197.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000166798700039
URI http://repositorio.unifesp.br/11600/44806

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