Laparoscopic evaluation of abdominal adhesions with different prosthetic meshes in rabbits

Laparoscopic evaluation of abdominal adhesions with different prosthetic meshes in rabbits

Autor Marcondes, Wagner Autor UNIFESP Google Scholar
Herbella, Fernando Augusto Mardiros Autor UNIFESP Google Scholar
Matone, Jacques Autor UNIFESP Google Scholar
Odashiro, Alexandre Nakao Autor UNIFESP Google Scholar
Goldenberg, Alberto Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: The use of prosthetic materials to reinforce the abdominal wall is associated with a low index of recurrence; however, intraperitoneal placement of a foreign body may lead to adhesions. The present investigation was designed to determine adhesion formation with commercially available meshes implanted laparoscopically in rabbits.Methods: Three different meshes were implanted laparoscopically in 24 rabbits: polypropylene (mesh A), polypropylene and sodium hyaluronate-carboxymethylecellulose (mesh B), and polypropylene and expanded polytetra-fluoroethylene (mesh C), Sites of implantation for each mesh (the left lower quadrant, right lower quadrant, and lower midline) were randomly determined so that every rabbit had all 3 meshes implanted. All animals underwent diagnostic laparoscopy after 28 days to grade adhesions and histological analysis of inflammation.Results: Adhesions were noticed in 46 of the 72 meshes implanted (64%). The number of adhesions was higher for mesh C (87.5%) compared with meshes A (62.5%) and B (41.6%). The severity of adhesions was also higher for mesh C (grade I in 14, II in 6, and III in 1) compared with mesh A (grade I in 10, II in 4, and III in 1 case) and B (all of them grade II). Histological inflammatory reaction was classified as mild in 23 cases of mesh A, 15 of mesh B, and 23 of mesh C. A moderate reaction was found in 1 case of mesh A, 4 cases of mesh B, and 1 case of mesh C. Severe reaction was induced in 5 cases of mesh B. Mesh B induced a higher inflammatory reaction compared with the other meshes.
Assunto adhesions
hernia repair
prosthetic materials
Idioma Inglês
Data 2008-01-01
Publicado em Jsls-journal Of The Society Of Laparoendoscopic Surgeons. Miami: Soc Laparoendoscopic Surgeons, v. 12, n. 1, p. 58-61, 2008.
ISSN 1086-8089 (Sherpa/Romeo, fator de impacto)
Editor Soc Laparoendoscopic Surgeons
Extensão 522-522
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000258750300010

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