The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: A double-blind, randomized, placebo-controlled clinical trial

The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: A double-blind, randomized, placebo-controlled clinical trial

Author Frisoli Junior, Alberto Autor UNIFESP Google Scholar
Chaves, Paulo Henrique M Google Scholar
Pinheiro, Marcelo de Medeiros Autor UNIFESP Google Scholar
Szejnfeld, Vera Lucia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Methods. In a randomized, double-blind, placebo-controlled clinical trial, we evaluated the effect of a 2-year treatment with nandrolone decanoate (ND) on bone mineral density (BMD) of lumbar spine, femoral neck, and trochanter and on vertebral fracture rate, muscle mass, and hemoglobin levels. Sixty-five osteoporotic women older than 70 years were studied. Thirty-two patients received injections of 50 mg ND, and 33 received placebos every 3 weeks. All patients received 500 mg calcium tablets daily.Results. Compared to baseline, ND increased the BMD of the lumbar spine (3.4% +/- 6.0 and 3.7% +/- 7.4: p < .05) and femoral neck (4.1% +/- 7.3 and 4.7% +/- 8.0: p < .05) after 1 and 2 years, respectively. The BMD of trochanter increased significantly only after the first year (4.8% +/- 9.3, p < .05). Compared to the placebo group, the ND group presented with significantly increased BMD of the trochanter and neck. ND significantly reduced incidence of new vertebral fractures (21% vs 43% in the placebo group; p < .05). ND showed a significant statistical increase in lean body mass after the first (6.2% +/- 5.8: p < .01) and second years (11.9% +/- 29.2: p < .01). In addition, a 2-year treatment with ND significantly increased hemoglobin levels compared to baseline (14.3%; p < .01) and placebo (p < .01).Conclusions. ND increased BMD, hemoglobin levels. and muscle mass, and reduced the vertebral fracture rate of elderly osteoporotic women.
Language English
Date 2005-05-01
Published in Journals Of Gerontology Series A-biological Sciences And Medical Sciences. Washington: Gerontological Society Amer, v. 60, n. 5, p. 648-653, 2005.
ISSN 1079-5006 (Sherpa/Romeo, impact factor)
Publisher Gerontological Society Amer
Extent 196-203
Origin http://dx.doi.org/10.1093/gerona/60.5.648
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000229921200023
URI http://repositorio.unifesp.br/11600/44801

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